TY - JOUR
T1 - Methylchloroisothiazolinone/methylisothiazolinone (Kathon CG) biocide
T2 - Second United States multicenter study of human skin sensitization
AU - Marks, James G.
AU - Moss, Jack N.
AU - Parno, Jeffrey R.
AU - Adams, Robert M.
AU - Belsito, Donald V.
AU - DeLeo, Vincent A.
AU - Fransway, Anthony
AU - Fowler, Joseph F.
AU - Maibach, Howard I.
AU - Toby Mathias, C. G.
AU - Nethercott, James R.
AU - Rietschel, Robert L.
AU - Sherertz, Elizabeth
AU - Storrs, Frances J.
AU - Taylor, James S.
PY - 1993/6
Y1 - 1993/6
N2 - Background: This is the second United States multicenter study of human skin sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI). From January 1991 through March 1992 patients treated in 11 patch test clinics were patch tested to 100 ppm MCI/MI, formaldehyde 1% aqueous, quaternium-15 2% petrolatum, imidazolidinyl urea 2% petrolatum, and paraben mix 12% petrolatum. Results: Twenty-three of the 1,259 patch test patients (1.8%) had positive patch test reactions to MCI/MI. Thirteen of the 23 (56.5%) were thought to be relevant to the presenting dermatitis. The frequency of positive patch test reactions to the other allergens was quaternium-15, 7.2%; formaldehyde, 7.1%; imidazolidinyl urea, 2.2%; and paraben mix, 1.4%. Conclusion: Skin sensitization to MCI/MI has not changed significantly since the first United States multicenter study in 1988 to 1989. The rate of positive patch test responses to MCI/MI was comparable with that for parabens and imidazolidinyl urea and significantly less than for formaldehyde and quaternium-15.
AB - Background: This is the second United States multicenter study of human skin sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI). From January 1991 through March 1992 patients treated in 11 patch test clinics were patch tested to 100 ppm MCI/MI, formaldehyde 1% aqueous, quaternium-15 2% petrolatum, imidazolidinyl urea 2% petrolatum, and paraben mix 12% petrolatum. Results: Twenty-three of the 1,259 patch test patients (1.8%) had positive patch test reactions to MCI/MI. Thirteen of the 23 (56.5%) were thought to be relevant to the presenting dermatitis. The frequency of positive patch test reactions to the other allergens was quaternium-15, 7.2%; formaldehyde, 7.1%; imidazolidinyl urea, 2.2%; and paraben mix, 1.4%. Conclusion: Skin sensitization to MCI/MI has not changed significantly since the first United States multicenter study in 1988 to 1989. The rate of positive patch test responses to MCI/MI was comparable with that for parabens and imidazolidinyl urea and significantly less than for formaldehyde and quaternium-15.
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U2 - 10.1097/01634989-199306000-00004
DO - 10.1097/01634989-199306000-00004
M3 - Article
AN - SCOPUS:0002917720
SN - 1710-3568
VL - 4
SP - 87
EP - 89
JO - Dermatitis : contact, atopic, occupational, drug
JF - Dermatitis : contact, atopic, occupational, drug
IS - 2
ER -