Methylchloroisothiazolinone-methylisothiazolinone reactions in patients screened for vehicle and preservative hypersensitivity

R. L. Rietschel, J. R. Nethercott, E. A. Emmett, H. I. Maibach, Frances Storrs, W. G. Larsen, R. M. Adams, J. S. Taylor, J. G. Marks, J. C. Mitchell, A. A. Fisher, N. B. Kanof, W. E. Clendenning, W. F. Schorr

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

More than 1100 patients were tested with methylchloroisothiazolinone-methylisothiazolinone, 100 ppm, in aqueous and petrolatum-based patch test materials from 1985 to 1987 by members of the North American Contact Dermatitis Group. Thirteen reactions to the aqueous materials and 10 to the petrolatum-based materials were observed. Irritant reactions were infrequent, and about half the reactions were deemed relevant. From 1984 to 1985, patch tests with this substance at a concentration of 250 ppm in petrolatum were conducted. Thirteen persons were identified as allergic, but three others were sensitized by the patch test procedure. Sensitization was not observed in tests with aqueous or petrolatum-based substance at a concentration of 100 ppm, and this concentration appears to be the best compromise between safety and sensitive detection of allergy. Use tests are helpful but not infallible as a guide in establishing relevance with methylchloroisothiazolinone-methylisothiazolinone. Wash-off products are frequently well tolerated by patients with positive reactions to this substance.

Original languageEnglish (US)
Pages (from-to)734-738
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume22
Issue number5 I
StatePublished - 1990
Externally publishedYes

Fingerprint

Petrolatum
Patch Tests
Hypersensitivity
Irritants
Contact Dermatitis
Safety
5-chloro-2-methyl-4-isothiazolin-3-one
2-methyl-4-isothiazolin-3-one

ASJC Scopus subject areas

  • Dermatology

Cite this

Rietschel, R. L., Nethercott, J. R., Emmett, E. A., Maibach, H. I., Storrs, F., Larsen, W. G., ... Schorr, W. F. (1990). Methylchloroisothiazolinone-methylisothiazolinone reactions in patients screened for vehicle and preservative hypersensitivity. Journal of the American Academy of Dermatology, 22(5 I), 734-738.

Methylchloroisothiazolinone-methylisothiazolinone reactions in patients screened for vehicle and preservative hypersensitivity. / Rietschel, R. L.; Nethercott, J. R.; Emmett, E. A.; Maibach, H. I.; Storrs, Frances; Larsen, W. G.; Adams, R. M.; Taylor, J. S.; Marks, J. G.; Mitchell, J. C.; Fisher, A. A.; Kanof, N. B.; Clendenning, W. E.; Schorr, W. F.

In: Journal of the American Academy of Dermatology, Vol. 22, No. 5 I, 1990, p. 734-738.

Research output: Contribution to journalArticle

Rietschel, RL, Nethercott, JR, Emmett, EA, Maibach, HI, Storrs, F, Larsen, WG, Adams, RM, Taylor, JS, Marks, JG, Mitchell, JC, Fisher, AA, Kanof, NB, Clendenning, WE & Schorr, WF 1990, 'Methylchloroisothiazolinone-methylisothiazolinone reactions in patients screened for vehicle and preservative hypersensitivity', Journal of the American Academy of Dermatology, vol. 22, no. 5 I, pp. 734-738.
Rietschel, R. L. ; Nethercott, J. R. ; Emmett, E. A. ; Maibach, H. I. ; Storrs, Frances ; Larsen, W. G. ; Adams, R. M. ; Taylor, J. S. ; Marks, J. G. ; Mitchell, J. C. ; Fisher, A. A. ; Kanof, N. B. ; Clendenning, W. E. ; Schorr, W. F. / Methylchloroisothiazolinone-methylisothiazolinone reactions in patients screened for vehicle and preservative hypersensitivity. In: Journal of the American Academy of Dermatology. 1990 ; Vol. 22, No. 5 I. pp. 734-738.
@article{89a5b7987a124eea87322ce28386407c,
title = "Methylchloroisothiazolinone-methylisothiazolinone reactions in patients screened for vehicle and preservative hypersensitivity",
abstract = "More than 1100 patients were tested with methylchloroisothiazolinone-methylisothiazolinone, 100 ppm, in aqueous and petrolatum-based patch test materials from 1985 to 1987 by members of the North American Contact Dermatitis Group. Thirteen reactions to the aqueous materials and 10 to the petrolatum-based materials were observed. Irritant reactions were infrequent, and about half the reactions were deemed relevant. From 1984 to 1985, patch tests with this substance at a concentration of 250 ppm in petrolatum were conducted. Thirteen persons were identified as allergic, but three others were sensitized by the patch test procedure. Sensitization was not observed in tests with aqueous or petrolatum-based substance at a concentration of 100 ppm, and this concentration appears to be the best compromise between safety and sensitive detection of allergy. Use tests are helpful but not infallible as a guide in establishing relevance with methylchloroisothiazolinone-methylisothiazolinone. Wash-off products are frequently well tolerated by patients with positive reactions to this substance.",
author = "Rietschel, {R. L.} and Nethercott, {J. R.} and Emmett, {E. A.} and Maibach, {H. I.} and Frances Storrs and Larsen, {W. G.} and Adams, {R. M.} and Taylor, {J. S.} and Marks, {J. G.} and Mitchell, {J. C.} and Fisher, {A. A.} and Kanof, {N. B.} and Clendenning, {W. E.} and Schorr, {W. F.}",
year = "1990",
language = "English (US)",
volume = "22",
pages = "734--738",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "5 I",

}

TY - JOUR

T1 - Methylchloroisothiazolinone-methylisothiazolinone reactions in patients screened for vehicle and preservative hypersensitivity

AU - Rietschel, R. L.

AU - Nethercott, J. R.

AU - Emmett, E. A.

AU - Maibach, H. I.

AU - Storrs, Frances

AU - Larsen, W. G.

AU - Adams, R. M.

AU - Taylor, J. S.

AU - Marks, J. G.

AU - Mitchell, J. C.

AU - Fisher, A. A.

AU - Kanof, N. B.

AU - Clendenning, W. E.

AU - Schorr, W. F.

PY - 1990

Y1 - 1990

N2 - More than 1100 patients were tested with methylchloroisothiazolinone-methylisothiazolinone, 100 ppm, in aqueous and petrolatum-based patch test materials from 1985 to 1987 by members of the North American Contact Dermatitis Group. Thirteen reactions to the aqueous materials and 10 to the petrolatum-based materials were observed. Irritant reactions were infrequent, and about half the reactions were deemed relevant. From 1984 to 1985, patch tests with this substance at a concentration of 250 ppm in petrolatum were conducted. Thirteen persons were identified as allergic, but three others were sensitized by the patch test procedure. Sensitization was not observed in tests with aqueous or petrolatum-based substance at a concentration of 100 ppm, and this concentration appears to be the best compromise between safety and sensitive detection of allergy. Use tests are helpful but not infallible as a guide in establishing relevance with methylchloroisothiazolinone-methylisothiazolinone. Wash-off products are frequently well tolerated by patients with positive reactions to this substance.

AB - More than 1100 patients were tested with methylchloroisothiazolinone-methylisothiazolinone, 100 ppm, in aqueous and petrolatum-based patch test materials from 1985 to 1987 by members of the North American Contact Dermatitis Group. Thirteen reactions to the aqueous materials and 10 to the petrolatum-based materials were observed. Irritant reactions were infrequent, and about half the reactions were deemed relevant. From 1984 to 1985, patch tests with this substance at a concentration of 250 ppm in petrolatum were conducted. Thirteen persons were identified as allergic, but three others were sensitized by the patch test procedure. Sensitization was not observed in tests with aqueous or petrolatum-based substance at a concentration of 100 ppm, and this concentration appears to be the best compromise between safety and sensitive detection of allergy. Use tests are helpful but not infallible as a guide in establishing relevance with methylchloroisothiazolinone-methylisothiazolinone. Wash-off products are frequently well tolerated by patients with positive reactions to this substance.

UR - http://www.scopus.com/inward/record.url?scp=0025286566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025286566&partnerID=8YFLogxK

M3 - Article

C2 - 2347960

AN - SCOPUS:0025286566

VL - 22

SP - 734

EP - 738

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 5 I

ER -