Methods of melanoma detection

Sancy A. Leachman; Pamela B. Cassidy; Suephy C. Chen; Clara Curiel; Alan Geller; Daniel Gareau; Giovanni Pellacani; James M. Grichnik; Josep Malvehy; Jeffrey North; Steven L. Jacques; Tracy Petrie; Susana Puig; Susan M. Swetter; Susan Tofte; Martin A. Weinstock

doi:10.1007/978-3-319-22539-5_3

Methods of melanoma detection

Sancy A. Leachman, Pamela B. Cassidy, Suephy C. Chen, Clara Curiel, Alan Geller, Daniel Gareau, Giovanni Pellacani, James M. Grichnik, Josep Malvehy, Jeffrey North, Steven L. Jacques, Tracy Petrie, Susana Puig, Susan M. Swetter, Susan Tofte, Martin A. Weinstock

Research output: Chapter in Book/Report/Conference proceeding › Chapter

31 Scopus citations

Abstract

Detection and removal of melanoma, before it has metastasized, dramatically improves prognosis and survival. The purpose of this chapter is to (1) summarize current methods of melanoma detection and (2) review state-of-the-art detection methods and technologies that have the potential to reduce melanoma mortality. Current strategies for the detection of melanoma range from population-based educational campaigns and screening to the use of algorithm-driven imaging technologies and performance of assays that identify markers of transformation.This chapter will begin by describing state-of-the-art methods for educating and increasing awareness of at-risk individuals and for performing comprehensive screening examinations. Standard and advanced photographic methods designed to improve reliability and reproducibility of the clinical examination will also be reviewed. Devices that magnify and/or enhance malignant features of individual melanocytic lesions (and algorithms that are available to interpret the results obtained from these devices) will be compared and contrasted. In vivo confocal microscopy and other cellular-level in vivo technologies will be compared to traditional tissue biopsy, and the role of a noninvasive “optical biopsy” in the clinical setting will be discussed. Finally, cellular and molecular methods that have been applied to the diagnosis of melanoma, such as comparative genomic hybridization (CGH), fluorescent in situ hybridization (FISH), and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), will be discussed.

Original language	English (US)
Title of host publication	Cancer Treatment and Research
Publisher	Kluwer Academic Publishers
Pages	51-105
Number of pages	55
DOIs	https://doi.org/10.1007/978-3-319-22539-5_3
State	Published - 2016

Publication series

Name	Cancer Treatment and Research
Volume	167
ISSN (Print)	0927-3042

Keywords

Atypical nevi
Dermoscopy
Fluorescence in situ hybridization (FISH)
Gene expression profiling
Hyperspectral imaging
In vivo confocal microscopy
Melanoma detection
Melanoma digital photography
Melanoma prevention
Melanoma screening
Optical biopsy
Optical coherence tomography
Quantitative real-time PCR (qRT-PCR)

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/978-3-319-22539-5_3

Cite this

Leachman, S. A., Cassidy, P. B., Chen, S. C., Curiel, C., Geller, A., Gareau, D., Pellacani, G., Grichnik, J. M., Malvehy, J., North, J., Jacques, S. L., Petrie, T., Puig, S., Swetter, S. M., Tofte, S., & Weinstock, M. A. (2016). Methods of melanoma detection. In Cancer Treatment and Research (pp. 51-105). (Cancer Treatment and Research; Vol. 167). Kluwer Academic Publishers. https://doi.org/10.1007/978-3-319-22539-5_3

Leachman, SA , Cassidy, PB, Chen, SC, Curiel, C, Geller, A, Gareau, D, Pellacani, G, Grichnik, JM, Malvehy, J, North, J, Jacques, SL, Petrie, T, Puig, S, Swetter, SM, Tofte, S & Weinstock, MA 2016, Methods of melanoma detection. in Cancer Treatment and Research. Cancer Treatment and Research, vol. 167, Kluwer Academic Publishers, pp. 51-105. https://doi.org/10.1007/978-3-319-22539-5_3

@inbook{2348e78c585443ee8cbe67c7efa0bcc2,

title = "Methods of melanoma detection",

abstract = "Detection and removal of melanoma, before it has metastasized, dramatically improves prognosis and survival. The purpose of this chapter is to (1) summarize current methods of melanoma detection and (2) review state-of-the-art detection methods and technologies that have the potential to reduce melanoma mortality. Current strategies for the detection of melanoma range from population-based educational campaigns and screening to the use of algorithm-driven imaging technologies and performance of assays that identify markers of transformation.This chapter will begin by describing state-of-the-art methods for educating and increasing awareness of at-risk individuals and for performing comprehensive screening examinations. Standard and advanced photographic methods designed to improve reliability and reproducibility of the clinical examination will also be reviewed. Devices that magnify and/or enhance malignant features of individual melanocytic lesions (and algorithms that are available to interpret the results obtained from these devices) will be compared and contrasted. In vivo confocal microscopy and other cellular-level in vivo technologies will be compared to traditional tissue biopsy, and the role of a noninvasive “optical biopsy” in the clinical setting will be discussed. Finally, cellular and molecular methods that have been applied to the diagnosis of melanoma, such as comparative genomic hybridization (CGH), fluorescent in situ hybridization (FISH), and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), will be discussed.",

keywords = "Atypical nevi, Dermoscopy, Fluorescence in situ hybridization (FISH), Gene expression profiling, Hyperspectral imaging, In vivo confocal microscopy, Melanoma detection, Melanoma digital photography, Melanoma prevention, Melanoma screening, Optical biopsy, Optical coherence tomography, Quantitative real-time PCR (qRT-PCR)",

author = "Leachman, {Sancy A.} and Cassidy, {Pamela B.} and Chen, {Suephy C.} and Clara Curiel and Alan Geller and Daniel Gareau and Giovanni Pellacani and Grichnik, {James M.} and Josep Malvehy and Jeffrey North and Jacques, {Steven L.} and Tracy Petrie and Susana Puig and Swetter, {Susan M.} and Susan Tofte and Weinstock, {Martin A.}",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2016.",

year = "2016",

doi = "10.1007/978-3-319-22539-5_3",

language = "English (US)",

series = "Cancer Treatment and Research",

publisher = "Kluwer Academic Publishers",

pages = "51--105",

booktitle = "Cancer Treatment and Research",

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TY - CHAP

T1 - Methods of melanoma detection

AU - Leachman, Sancy A.

AU - Cassidy, Pamela B.

AU - Chen, Suephy C.

AU - Curiel, Clara

AU - Geller, Alan

AU - Gareau, Daniel

AU - Pellacani, Giovanni

AU - Grichnik, James M.

AU - Malvehy, Josep

AU - North, Jeffrey

AU - Jacques, Steven L.

AU - Petrie, Tracy

AU - Puig, Susana

AU - Swetter, Susan M.

AU - Tofte, Susan

AU - Weinstock, Martin A.

N1 - Publisher Copyright: © Springer International Publishing Switzerland 2016.

PY - 2016

Y1 - 2016

N2 - Detection and removal of melanoma, before it has metastasized, dramatically improves prognosis and survival. The purpose of this chapter is to (1) summarize current methods of melanoma detection and (2) review state-of-the-art detection methods and technologies that have the potential to reduce melanoma mortality. Current strategies for the detection of melanoma range from population-based educational campaigns and screening to the use of algorithm-driven imaging technologies and performance of assays that identify markers of transformation.This chapter will begin by describing state-of-the-art methods for educating and increasing awareness of at-risk individuals and for performing comprehensive screening examinations. Standard and advanced photographic methods designed to improve reliability and reproducibility of the clinical examination will also be reviewed. Devices that magnify and/or enhance malignant features of individual melanocytic lesions (and algorithms that are available to interpret the results obtained from these devices) will be compared and contrasted. In vivo confocal microscopy and other cellular-level in vivo technologies will be compared to traditional tissue biopsy, and the role of a noninvasive “optical biopsy” in the clinical setting will be discussed. Finally, cellular and molecular methods that have been applied to the diagnosis of melanoma, such as comparative genomic hybridization (CGH), fluorescent in situ hybridization (FISH), and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), will be discussed.

AB - Detection and removal of melanoma, before it has metastasized, dramatically improves prognosis and survival. The purpose of this chapter is to (1) summarize current methods of melanoma detection and (2) review state-of-the-art detection methods and technologies that have the potential to reduce melanoma mortality. Current strategies for the detection of melanoma range from population-based educational campaigns and screening to the use of algorithm-driven imaging technologies and performance of assays that identify markers of transformation.This chapter will begin by describing state-of-the-art methods for educating and increasing awareness of at-risk individuals and for performing comprehensive screening examinations. Standard and advanced photographic methods designed to improve reliability and reproducibility of the clinical examination will also be reviewed. Devices that magnify and/or enhance malignant features of individual melanocytic lesions (and algorithms that are available to interpret the results obtained from these devices) will be compared and contrasted. In vivo confocal microscopy and other cellular-level in vivo technologies will be compared to traditional tissue biopsy, and the role of a noninvasive “optical biopsy” in the clinical setting will be discussed. Finally, cellular and molecular methods that have been applied to the diagnosis of melanoma, such as comparative genomic hybridization (CGH), fluorescent in situ hybridization (FISH), and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), will be discussed.

KW - Atypical nevi

KW - Dermoscopy

KW - Fluorescence in situ hybridization (FISH)

KW - Gene expression profiling

KW - Hyperspectral imaging

KW - In vivo confocal microscopy

KW - Melanoma detection

KW - Melanoma digital photography

KW - Melanoma prevention

KW - Melanoma screening

KW - Optical biopsy

KW - Optical coherence tomography

KW - Quantitative real-time PCR (qRT-PCR)

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U2 - 10.1007/978-3-319-22539-5_3

DO - 10.1007/978-3-319-22539-5_3

M3 - Chapter

C2 - 26601859

AN - SCOPUS:84948845040

T3 - Cancer Treatment and Research

SP - 51

EP - 105

BT - Cancer Treatment and Research

PB - Kluwer Academic Publishers

ER -

Methods of melanoma detection

Abstract

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Keywords

ASJC Scopus subject areas

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