Methamphetamine and the hypothalamic-pituitary-adrenal axis

Damian G. Zuloaga, Jason S. Jacosbskind, Jacob Raber

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the HPA axis, including effects on HPA axis associated genes/proteins, brain regions, and behaviors such as anxiety and depression. A better understanding of the mechanisms through which MA affects the HPA axis may lead to more effective treatment strategies for MA addiction.

Original languageEnglish (US)
Pages (from-to)178
Number of pages1
JournalFrontiers in Neuroscience
Volume9
Issue numberMAY
DOIs
StatePublished - 2015

Fingerprint

Methamphetamine
Anxiety
Depression
Recurrence
Brain
Proteins

Keywords

  • Anxiety
  • Glucocorticoids
  • HPA axis
  • Methamphetamine
  • Stress
  • Substance abuse

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Methamphetamine and the hypothalamic-pituitary-adrenal axis. / Zuloaga, Damian G.; Jacosbskind, Jason S.; Raber, Jacob.

In: Frontiers in Neuroscience, Vol. 9, No. MAY, 2015, p. 178.

Research output: Contribution to journalArticle

Zuloaga, Damian G. ; Jacosbskind, Jason S. ; Raber, Jacob. / Methamphetamine and the hypothalamic-pituitary-adrenal axis. In: Frontiers in Neuroscience. 2015 ; Vol. 9, No. MAY. pp. 178.
@article{a0b0013eba0f427f979b6b29805bf63b,
title = "Methamphetamine and the hypothalamic-pituitary-adrenal axis",
abstract = "Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the HPA axis, including effects on HPA axis associated genes/proteins, brain regions, and behaviors such as anxiety and depression. A better understanding of the mechanisms through which MA affects the HPA axis may lead to more effective treatment strategies for MA addiction.",
keywords = "Anxiety, Glucocorticoids, HPA axis, Methamphetamine, Stress, Substance abuse",
author = "Zuloaga, {Damian G.} and Jacosbskind, {Jason S.} and Jacob Raber",
year = "2015",
doi = "10.3389/fnins.2015.00178",
language = "English (US)",
volume = "9",
pages = "178",
journal = "Frontiers in Neuroscience",
issn = "1662-4548",
publisher = "Frontiers Research Foundation",
number = "MAY",

}

TY - JOUR

T1 - Methamphetamine and the hypothalamic-pituitary-adrenal axis

AU - Zuloaga, Damian G.

AU - Jacosbskind, Jason S.

AU - Raber, Jacob

PY - 2015

Y1 - 2015

N2 - Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the HPA axis, including effects on HPA axis associated genes/proteins, brain regions, and behaviors such as anxiety and depression. A better understanding of the mechanisms through which MA affects the HPA axis may lead to more effective treatment strategies for MA addiction.

AB - Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the HPA axis, including effects on HPA axis associated genes/proteins, brain regions, and behaviors such as anxiety and depression. A better understanding of the mechanisms through which MA affects the HPA axis may lead to more effective treatment strategies for MA addiction.

KW - Anxiety

KW - Glucocorticoids

KW - HPA axis

KW - Methamphetamine

KW - Stress

KW - Substance abuse

UR - http://www.scopus.com/inward/record.url?scp=84930654917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930654917&partnerID=8YFLogxK

U2 - 10.3389/fnins.2015.00178

DO - 10.3389/fnins.2015.00178

M3 - Article

AN - SCOPUS:84930654917

VL - 9

SP - 178

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-4548

IS - MAY

ER -