Methamphetamine and the hypothalamic-pituitary-adrenal axis

Damian G. Zuloaga, Jason S. Jacosbskind, Jacob Raber

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the HPA axis, including effects on HPA axis associated genes/proteins, brain regions, and behaviors such as anxiety and depression. A better understanding of the mechanisms through which MA affects the HPA axis may lead to more effective treatment strategies for MA addiction.

Original languageEnglish (US)
Pages (from-to)178
Number of pages1
JournalFrontiers in Neuroscience
Volume9
Issue numberMAY
DOIs
StatePublished - 2015

Keywords

  • Anxiety
  • Glucocorticoids
  • HPA axis
  • Methamphetamine
  • Stress
  • Substance abuse

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Methamphetamine and the hypothalamic-pituitary-adrenal axis'. Together they form a unique fingerprint.

Cite this