Methamphetamine and the hypothalamic-pituitary-adrenal axis

Damian G. Zuloaga, Jason S. Jacosbskind, Jacob Raber

Research output: Contribution to journalArticle

24 Scopus citations


Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the HPA axis, including effects on HPA axis associated genes/proteins, brain regions, and behaviors such as anxiety and depression. A better understanding of the mechanisms through which MA affects the HPA axis may lead to more effective treatment strategies for MA addiction.

Original languageEnglish (US)
Number of pages1
JournalFrontiers in Neuroscience
Issue numberMAY
StatePublished - 2015


  • Anxiety
  • Glucocorticoids
  • HPA axis
  • Methamphetamine
  • Stress
  • Substance abuse

ASJC Scopus subject areas

  • Neuroscience(all)

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