Metformin does not affect risk of biochemical recurrence following radical prostatectomy: Results from the SEARCH database

E. H. Allott, M. R. Abern, L. Gerber, C. J. Keto, W. J. Aronson, M. K. Terris, C. J. Kane, Christopher Amling, M. R. Cooperberg, P. G. Moorman, S. J. Freedland

Research output: Contribution to journalArticle

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Abstract

Background:While epidemiologic studies suggest that metformin use among diabetics may decrease prostate cancer (PC) incidence, the effect of metformin use on PC outcome is unclear. We investigated the association between pre-operative metformin use, dose and duration of use and biochemical recurrence (BCR) in PC patients with diabetes who underwent radical prostatectomy (RP).Methods:We conducted a retrospective cohort analysis within the Shared Equal Access Regional Cancer Hospital (SEARCH) database of 371 PC patients with diabetes who underwent RP. Time to BCR between metformin users and non-users, and by metformin dose and duration of use was assessed using multivariable Cox proportional analysis adjusted for demographic, clinical and/or pathologic features. Time to castrate-resistant PC (CRPC), metastases and PC-specific mortality were explored as secondary outcomes using unadjusted analyses.Results:Of 371 diabetic men, 156 (42%) were using metformin before RP. Metformin use was associated with more recent year of surgery (P

Original languageEnglish (US)
Pages (from-to)391-397
Number of pages7
JournalProstate Cancer and Prostatic Diseases
Volume16
Issue number4
DOIs
StatePublished - Dec 2013

Fingerprint

Cancer Care Facilities
Metformin
Prostatectomy
Prostatic Neoplasms
Databases
Recurrence
Epidemiologic Studies
Cohort Studies
Demography
Neoplasm Metastasis
Mortality
Incidence

Keywords

  • Biochemical recurrence
  • Diabetes
  • Metformin
  • Outcomes

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Cite this

Allott, E. H., Abern, M. R., Gerber, L., Keto, C. J., Aronson, W. J., Terris, M. K., ... Freedland, S. J. (2013). Metformin does not affect risk of biochemical recurrence following radical prostatectomy: Results from the SEARCH database. Prostate Cancer and Prostatic Diseases, 16(4), 391-397. https://doi.org/10.1038/pcan.2013.48

Metformin does not affect risk of biochemical recurrence following radical prostatectomy : Results from the SEARCH database. / Allott, E. H.; Abern, M. R.; Gerber, L.; Keto, C. J.; Aronson, W. J.; Terris, M. K.; Kane, C. J.; Amling, Christopher; Cooperberg, M. R.; Moorman, P. G.; Freedland, S. J.

In: Prostate Cancer and Prostatic Diseases, Vol. 16, No. 4, 12.2013, p. 391-397.

Research output: Contribution to journalArticle

Allott, EH, Abern, MR, Gerber, L, Keto, CJ, Aronson, WJ, Terris, MK, Kane, CJ, Amling, C, Cooperberg, MR, Moorman, PG & Freedland, SJ 2013, 'Metformin does not affect risk of biochemical recurrence following radical prostatectomy: Results from the SEARCH database', Prostate Cancer and Prostatic Diseases, vol. 16, no. 4, pp. 391-397. https://doi.org/10.1038/pcan.2013.48
Allott, E. H. ; Abern, M. R. ; Gerber, L. ; Keto, C. J. ; Aronson, W. J. ; Terris, M. K. ; Kane, C. J. ; Amling, Christopher ; Cooperberg, M. R. ; Moorman, P. G. ; Freedland, S. J. / Metformin does not affect risk of biochemical recurrence following radical prostatectomy : Results from the SEARCH database. In: Prostate Cancer and Prostatic Diseases. 2013 ; Vol. 16, No. 4. pp. 391-397.
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