Abstract
Metastatic prostate cancer has a strong predilection for osseous sites, where the disease spreads in 80% of advanced cases. The molecular mechanisms involved in prostate cancer establishment in bone are largely unknown; however, local tissue factors, including those involved in wound healing, have been suggested to play a critical role. We present a case of tumor explosion in a median sternotomy wound after local prostate cancer therapy. This case highlights that novel therapeutic interventions that disrupt the apparent synergistic relationship between tumor cells and the pro-tumorigenic microenvironment may hold great promise in constraining the proliferation of prostate cancer metastases.
Original language | English (US) |
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Pages (from-to) | 204.e13 |
Journal | Urology |
Volume | 68 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2006 |
ASJC Scopus subject areas
- Urology