Metaphyseal bone lesions in young dogs with systemic canine distemper virus infection

W. Baumgärtner, R. W. Boyce, S. Alldinger, Michael Axthelm, S. E. Weisbrode, S. Krakowka, K. Gaedke

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Bone lesions, restricted to the metaphyses of long bones, were observed in young dogs with systemic distemper following experimental and spontaneous infection. Canine distemper virus (CDV) antigen was found immunocytochemically in hematopoietic marrow cells, osteoclasts, osteoblasts and rarely in osteocytes. In experimentally infected dogs, viral antigen was demonstrated in the metaphysis between 5 and 36 days after infection. Associated lesions, characterized by necrosis of osteoclasts, persistence of primary spongiosa and atrophy and necrosis of osteoblasts and marrow cells, were mild and most prominent between 8 and 32 days postinfection. Metaphyseal osteosclerosis (MO) of the long bones, varying from mild to severe, was observed macroscopically in 8 (19%) out of 42 dogs with spontaneous distemper. Affected animals were between 3 and 6 months of age and belonged mainly to the large breeds. In these animals, MO was characterized histologically by persistence of primary spongiosa, loss of bone marrow cells and necrosis of osteoclasts and bone marrow cells varying from mild to severe. Summarized, CDV-associated bone lesions were only transient and there were no indications of viral persistence in bones of dogs experimentally infected with CDV. Although no clinical signs related to the bones were observed, the present study reveals that infection of metaphyseal bone cells is common in young dogs with systemic distemper and occurrence of viral antigen in these cells results in defects in bone modelling.

Original languageEnglish (US)
Pages (from-to)201-209
Number of pages9
JournalVeterinary Microbiology
Volume44
Issue number2-4
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Canine Distemper Virus
Canine distemper virus
Virus Diseases
lesions (animal)
bones
Dogs
Bone and Bones
dogs
Distemper
distemper
infection
osteoclasts
Osteoclasts
Osteosclerosis
necrosis
Viral Antigens
osteoblasts
viral antigens
bone marrow cells
Osteoblasts

Keywords

  • Canine distemper virus
  • Dog
  • Metaphysis
  • Osteosclerosis
  • Paget's bone disease
  • Paramyxovirus

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)
  • Animal Science and Zoology

Cite this

Baumgärtner, W., Boyce, R. W., Alldinger, S., Axthelm, M., Weisbrode, S. E., Krakowka, S., & Gaedke, K. (1995). Metaphyseal bone lesions in young dogs with systemic canine distemper virus infection. Veterinary Microbiology, 44(2-4), 201-209. https://doi.org/10.1016/0378-1135(95)00013-Z

Metaphyseal bone lesions in young dogs with systemic canine distemper virus infection. / Baumgärtner, W.; Boyce, R. W.; Alldinger, S.; Axthelm, Michael; Weisbrode, S. E.; Krakowka, S.; Gaedke, K.

In: Veterinary Microbiology, Vol. 44, No. 2-4, 1995, p. 201-209.

Research output: Contribution to journalArticle

Baumgärtner, W, Boyce, RW, Alldinger, S, Axthelm, M, Weisbrode, SE, Krakowka, S & Gaedke, K 1995, 'Metaphyseal bone lesions in young dogs with systemic canine distemper virus infection', Veterinary Microbiology, vol. 44, no. 2-4, pp. 201-209. https://doi.org/10.1016/0378-1135(95)00013-Z
Baumgärtner, W. ; Boyce, R. W. ; Alldinger, S. ; Axthelm, Michael ; Weisbrode, S. E. ; Krakowka, S. ; Gaedke, K. / Metaphyseal bone lesions in young dogs with systemic canine distemper virus infection. In: Veterinary Microbiology. 1995 ; Vol. 44, No. 2-4. pp. 201-209.
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