Metals in urine in relation to the prevalence of pre-diabetes, diabetes and atherosclerosis in rural India

Ganesan Velmurugan, Krishnan Swaminathan, Ganesh Veerasekar, Jonathan Q. Purnell, Sundaresan Mohanraj, Mani Dhivakar, Anil Kumar Avula, Mathew Cherian, Nalla G. Palaniswami, Thomas Alexander, Thalappil Pradeep

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective: Diabetes and cardiovascular diseases are growing burdens in rural communities worldwide. We have observed a high prevalence of diabetes among rural farming communities in India and sought to evaluate the association of non-traditional risk factors, such as metals, with diabetes and other cardiometabolic risk factors in this community. Methods: Anthropometric measurements, chemistries and carotid intima-media thickness were determined in 865 participants of the Kovai Medical Center and Hospital-Nallampatti Non-Communicable Disease Study-I (KMCH-NNCD-I, 2015), a cross-sectional study conducted in a farming village in South India. Urinary metal levels were determined by inductively couped plasma-mass spectrometry analysis and corrected to urinary creatinine level. Statistical analyses were performed to study the association between urinary metal levels and clinical parameters. Results: 82.5% of the study population were involved in farming and high levels of toxic metals were detected in the synthetic fertilisers used in the study village. The prevalence of pre-diabetes, diabetes and atherosclerosis was 43.4%, 16.2% and 10.3%, respectively. On logistic regression analysis, no association of traditional risk factors such as body mass index, blood pressure and total cholesterol with disease conditions was observed, but urinary levels of metals such as arsenic, chromium, aluminium and zinc showed an association with diabetes, while arsenic and zinc showed an association with pre-diabetes and atherosclerosis. Conclusions: Our data suggest a probable role of metals in the aetiology of diabetes and cardiovascular diseases in rural communities. Identifying and eliminating the causes of increased levels of these environmental chemicals could have a beneficial impact on the burden of non-communicable diseases in rural population.

Original languageEnglish (US)
Pages (from-to)661-667
Number of pages7
JournalOccupational and Environmental Medicine
Volume75
Issue number9
DOIs
StatePublished - Sep 2018

Keywords

  • arsenic
  • atherosclerosis
  • cardiometabolic risk factors
  • diabetes
  • metals
  • pre-diabetes
  • rural health

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'Metals in urine in relation to the prevalence of pre-diabetes, diabetes and atherosclerosis in rural India'. Together they form a unique fingerprint.

  • Cite this

    Velmurugan, G., Swaminathan, K., Veerasekar, G., Purnell, J. Q., Mohanraj, S., Dhivakar, M., Avula, A. K., Cherian, M., Palaniswami, N. G., Alexander, T., & Pradeep, T. (2018). Metals in urine in relation to the prevalence of pre-diabetes, diabetes and atherosclerosis in rural India. Occupational and Environmental Medicine, 75(9), 661-667. https://doi.org/10.1136/oemed-2018-104996