Metal uptake by manganese superoxide dismutase

James W. Whittaker

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Manganese superoxide dismutase is an important antioxidant defense metalloenzyme that protects cells from damage by the toxic oxygen metabolite, superoxide free radical, formed as an unavoidable by-product of aerobic metabolism. Many years of research have gone into understanding how the metal cofactor interacts with small molecules in its catalytic role. In contrast, very little is presently known about how the protein acquires its metal cofactor, an important step in the maturation of the protein and one that is absolutely required for its biological function. Recent work is beginning to provide insight into the mechanisms of metal delivery to manganese superoxide dismutase in vivo and in vitro.

Original languageEnglish (US)
Pages (from-to)298-307
Number of pages10
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Volume1804
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • Activation
  • Antioxidant
  • Apoprotein
  • Free radical
  • Metal binding
  • Metallation
  • Metallochaperone
  • Metalloenzyme
  • Metalloprotein

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biophysics
  • Biochemistry
  • Molecular Biology

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