Metabolic syndrome derived from principal component analysis and incident cardiovascular events: The multi ethnic study of atherosclerosis (MESA) and health, aging, and body composition (Health ABC)

Subhashish Agarwal, David R. Jacobs, Dhananjay Vaidya, Christopher Sibley, Neal W. Jorgensen, Jerome I. Rotter, Yii Der Ida Chen, Yongmei Liu, Jeanette S. Andrews, Stephen Kritchevsky, Bret Goodpaster, Alka Kanaya, Anne B. Newman, Eleanor M. Simonsick, David M. Herrington

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background. The NCEP metabolic syndrome (MetS) is a combination of dichotomized interrelated risk factors from predominantly Caucasian populations. We propose a continuous MetS score based on principal component analysis (PCA) of the same risk factors in a multiethnic cohort and compare prediction of incident CVD events with NCEP MetS definition. Additionally, we replicated these analyses in the Health, Aging, and Body composition (Health ABC) study cohort. Methods and Results. We performed PCA of the MetS elements (waist circumference, HDL, TG, fasting blood glucose, SBP, and DBP) in 2610 Caucasian Americans, 801 Chinese Americans, 1875 African Americans, and 1494 Hispanic Americans in the multiethnic study of atherosclerosis (MESA) cohort. We selected the first principal component as a continuous MetS score (MetS-PC). Cox proportional hazards models were used to examine the association between MetS-PC and 5.5 years of CVD events (n=377) adjusting for age, gender, race, smoking and LDL-C, overall and by ethnicity. To facilitate comparison of MetS-PC with the binary NCEP definition, a MetS-PC cut point was chosen to yield the same 37% prevalence of MetS as the NCEP definition (37%) in the MESA cohort. Hazard ratio (HR) for CVD events were estimated using the NCEP and Mets-PC-derived binary definitions. In Cox proportional models, the HR (95% CI) for CVD events for 1-SD (standard deviation) of MetS-PC was 1.71 (1.54-1.90) (P

Original languageEnglish (US)
Article number919425
JournalCardiology Research and Practice
Volume1
Issue number1
DOIs
StatePublished - 2012
Externally publishedYes

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Body Composition
Principal Component Analysis
Atherosclerosis
Health
Cohort Studies
Proportional Hazards Models
Asian Americans
Waist Circumference
Hispanic Americans
African Americans
Blood Glucose
Fasting
Smoking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Metabolic syndrome derived from principal component analysis and incident cardiovascular events : The multi ethnic study of atherosclerosis (MESA) and health, aging, and body composition (Health ABC). / Agarwal, Subhashish; Jacobs, David R.; Vaidya, Dhananjay; Sibley, Christopher; Jorgensen, Neal W.; Rotter, Jerome I.; Chen, Yii Der Ida; Liu, Yongmei; Andrews, Jeanette S.; Kritchevsky, Stephen; Goodpaster, Bret; Kanaya, Alka; Newman, Anne B.; Simonsick, Eleanor M.; Herrington, David M.

In: Cardiology Research and Practice, Vol. 1, No. 1, 919425, 2012.

Research output: Contribution to journalArticle

Agarwal, S, Jacobs, DR, Vaidya, D, Sibley, C, Jorgensen, NW, Rotter, JI, Chen, YDI, Liu, Y, Andrews, JS, Kritchevsky, S, Goodpaster, B, Kanaya, A, Newman, AB, Simonsick, EM & Herrington, DM 2012, 'Metabolic syndrome derived from principal component analysis and incident cardiovascular events: The multi ethnic study of atherosclerosis (MESA) and health, aging, and body composition (Health ABC)', Cardiology Research and Practice, vol. 1, no. 1, 919425. https://doi.org/10.1155/2012/919425
Agarwal, Subhashish ; Jacobs, David R. ; Vaidya, Dhananjay ; Sibley, Christopher ; Jorgensen, Neal W. ; Rotter, Jerome I. ; Chen, Yii Der Ida ; Liu, Yongmei ; Andrews, Jeanette S. ; Kritchevsky, Stephen ; Goodpaster, Bret ; Kanaya, Alka ; Newman, Anne B. ; Simonsick, Eleanor M. ; Herrington, David M. / Metabolic syndrome derived from principal component analysis and incident cardiovascular events : The multi ethnic study of atherosclerosis (MESA) and health, aging, and body composition (Health ABC). In: Cardiology Research and Practice. 2012 ; Vol. 1, No. 1.
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abstract = "Background. The NCEP metabolic syndrome (MetS) is a combination of dichotomized interrelated risk factors from predominantly Caucasian populations. We propose a continuous MetS score based on principal component analysis (PCA) of the same risk factors in a multiethnic cohort and compare prediction of incident CVD events with NCEP MetS definition. Additionally, we replicated these analyses in the Health, Aging, and Body composition (Health ABC) study cohort. Methods and Results. We performed PCA of the MetS elements (waist circumference, HDL, TG, fasting blood glucose, SBP, and DBP) in 2610 Caucasian Americans, 801 Chinese Americans, 1875 African Americans, and 1494 Hispanic Americans in the multiethnic study of atherosclerosis (MESA) cohort. We selected the first principal component as a continuous MetS score (MetS-PC). Cox proportional hazards models were used to examine the association between MetS-PC and 5.5 years of CVD events (n=377) adjusting for age, gender, race, smoking and LDL-C, overall and by ethnicity. To facilitate comparison of MetS-PC with the binary NCEP definition, a MetS-PC cut point was chosen to yield the same 37{\%} prevalence of MetS as the NCEP definition (37{\%}) in the MESA cohort. Hazard ratio (HR) for CVD events were estimated using the NCEP and Mets-PC-derived binary definitions. In Cox proportional models, the HR (95{\%} CI) for CVD events for 1-SD (standard deviation) of MetS-PC was 1.71 (1.54-1.90) (P",
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AU - Jacobs, David R.

AU - Vaidya, Dhananjay

AU - Sibley, Christopher

AU - Jorgensen, Neal W.

AU - Rotter, Jerome I.

AU - Chen, Yii Der Ida

AU - Liu, Yongmei

AU - Andrews, Jeanette S.

AU - Kritchevsky, Stephen

AU - Goodpaster, Bret

AU - Kanaya, Alka

AU - Newman, Anne B.

AU - Simonsick, Eleanor M.

AU - Herrington, David M.

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N2 - Background. The NCEP metabolic syndrome (MetS) is a combination of dichotomized interrelated risk factors from predominantly Caucasian populations. We propose a continuous MetS score based on principal component analysis (PCA) of the same risk factors in a multiethnic cohort and compare prediction of incident CVD events with NCEP MetS definition. Additionally, we replicated these analyses in the Health, Aging, and Body composition (Health ABC) study cohort. Methods and Results. We performed PCA of the MetS elements (waist circumference, HDL, TG, fasting blood glucose, SBP, and DBP) in 2610 Caucasian Americans, 801 Chinese Americans, 1875 African Americans, and 1494 Hispanic Americans in the multiethnic study of atherosclerosis (MESA) cohort. We selected the first principal component as a continuous MetS score (MetS-PC). Cox proportional hazards models were used to examine the association between MetS-PC and 5.5 years of CVD events (n=377) adjusting for age, gender, race, smoking and LDL-C, overall and by ethnicity. To facilitate comparison of MetS-PC with the binary NCEP definition, a MetS-PC cut point was chosen to yield the same 37% prevalence of MetS as the NCEP definition (37%) in the MESA cohort. Hazard ratio (HR) for CVD events were estimated using the NCEP and Mets-PC-derived binary definitions. In Cox proportional models, the HR (95% CI) for CVD events for 1-SD (standard deviation) of MetS-PC was 1.71 (1.54-1.90) (P

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