Metabolic syndrome and cognitive decline among the oldest old in Okinawa: In search of a mechanism. The KOCOA project

Yuriko Katsumata, Hidemi Todoriki, Yasushi Higashiuesato, Shotoku Yasura, D. Craig Willcox, Yusuke Ohya, Bradley J. Willcox, Hiroko H. Dodge

Research output: Contribution to journalArticle

34 Scopus citations


It has recently been demonstrated that as the ratio of protein to carbohydrate (P:C) in the diet declines, life span increases in Drosophila. Here we explored how extremely low dietary ratios of protein to carbohydrate affected longevity and a selection of variables associated with functional senescence. An increase in P:C ratio from 1:57 to 1:20 shortened life span by increasing age-dependent mortality; whereas a further decline in P:C from 1:57 to 1:95 caused a modest decrease in life span. Female flies consuming the 1:20 and 1:38 diets laid more eggs than those consuming the lower P:C diets. Flies fed diets with higher ratios were more resistant to heat stress. Flies consuming the diets with lowest P:C ratios needed more time to restore activity after paralysis. Our study has therefore extended to very low P:C ratios available data demonstrating that dietary P:C ratio affects life span, fecundity and heat stress resistance, with fecundity and heat stress responses showing the opposite trend to life span.

Original languageEnglish (US)
Pages (from-to)126-134
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67 A
Issue number2
StatePublished - Feb 2012



  • Drosophila melanogaster
  • Fecundity
  • Heat shock
  • Life span
  • Protein-to-carbohydrate ratio

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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