Metabolic stress and cardiovascular disease in diabetes mellitus: The role of protein O -GlcNAc modification

Yabing Chen, Xinyang Zhao, Hui Wu

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Mammalian cells metabolize glucose primarily for energy production, biomass synthesis, and posttranslational glycosylation; and maintaining glucose metabolic homeostasis is essential for normal physiology of cells. Impaired glucose homeostasis leads to hyperglycemia, a hallmark of diabetes mellitus. Chronically increased glucose in diabetes mellitus promotes pathological changes accompanied by impaired cellular function and tissue damage, which facilitates the development of cardiovascular complications, the major cause of morbidity and mortality of patients with diabetes mellitus. Emerging roles of glucose metabolism via the hexosamine biosynthesis pathway (HBP) and increased protein modification via O-linked β-N-acetylglucosamine (O-GlcNAcylation) have been demonstrated in diabetes mellitus and implicated in the development of diabetic cardiovascular complications. This review will discuss the biological outcomes of the glucose metabolism via the hexosamine biogenesis pathway and protein O-GlcNAcylation in regulating cellular homeostasis, and highlight the regulations and contributions of elevated O-GlcNAcylation to the pathogenesis of diabetic cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1911-1924
Number of pages14
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number10
StatePublished - Oct 1 2019
Externally publishedYes


  • Acetylglucosamine
  • Cardiovascular disease
  • Diabetes mellitus
  • Hexosamines
  • Hyperglycemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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