Metabolic acidosis decreases fetal myocardial isovolumic velocities in a chronic sheep model of increased placental vascular resistance

Ganesh Acharya, Juha Rasanen, Kaarin Mäkikallio, Tiina Erkinaro, Tomi Kavasmaa, Mervi Haapsamo, Luc Mertens, James C. Huhta

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We hypothesized that acute fetal metabolic acidosis decreases fetal myocardial motion in a chronic sheep model of increased placental vascular resistance (Rua). Eleven ewes and fetuses were instrumented at 118-122 days of gestation. After 5 days of recovery and 24 h of placental embolization to increase Rua, longitudinal myocardial velocities of the right and left ventricles and interventricular septum (IVS) were assessed at the level of the atrioventricular valve annuli via tissue Doppler imaging (TDI). Ventricular inflow (E and A waves) and outflow velocities were obtained, and cardiac outputs were calculated. All measurements were performed at baseline and during fetal acidosis caused by epidural anesthesia-induced maternal hypotension, which decreased uterine artery volume blood flow, fetal oxygenation, arterial pH, and base excess and increased lactate. Compared with baseline, the peak isovolumic myocardial contraction and relaxation velocities of the ventricles and IVS, early relaxation velocity (E′) of the ventricles, and systolic velocity of the IVS decreased during metabolic acidosis. The proportion of isovolumic contraction time of the cardiac cycle increased but the isovolumic relaxation and ejection time proportions and the TDI Tei index did not change. The E-to-E′ ratio for both ventricles was higher during metabolic acidosis than at baseline. During metabolic acidosis, right and left ventricular cardiac outputs remained unchanged compared with baseline. In sheep fetuses with increased Rua and acute metabolic acidosis, global cardiac function was preserved. However, acute metabolic acidosis impaired myocardial contractility during the isovolumic phase and relaxation during the isovolumic and early filling phases of the cardiac cycle.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume294
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Acidosis
Vascular Resistance
Sheep
Cardiac Output
Heart Ventricles
Fetus
Controlled Hypotension
Myocardial Contraction
Uterine Artery
Epidural Anesthesia
Blood Volume
Fetal Blood
Lactic Acid
Mothers
Pregnancy

Keywords

  • Cardiac function
  • Fetal echocardiography
  • Tissue Doppler

ASJC Scopus subject areas

  • Physiology

Cite this

Metabolic acidosis decreases fetal myocardial isovolumic velocities in a chronic sheep model of increased placental vascular resistance. / Acharya, Ganesh; Rasanen, Juha; Mäkikallio, Kaarin; Erkinaro, Tiina; Kavasmaa, Tomi; Haapsamo, Mervi; Mertens, Luc; Huhta, James C.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 294, No. 1, 01.2008.

Research output: Contribution to journalArticle

Acharya, Ganesh ; Rasanen, Juha ; Mäkikallio, Kaarin ; Erkinaro, Tiina ; Kavasmaa, Tomi ; Haapsamo, Mervi ; Mertens, Luc ; Huhta, James C. / Metabolic acidosis decreases fetal myocardial isovolumic velocities in a chronic sheep model of increased placental vascular resistance. In: American Journal of Physiology - Heart and Circulatory Physiology. 2008 ; Vol. 294, No. 1.
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