Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia

G. Escherich, S. Richards, Linda Stork, A. J. Vora

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Mercaptopurine has been used in continuing treatment of childhood acute lymphoblastic leukaemia since the mid 1950s. Recent advances in the understanding of thiopurine pharmacology indicated that thioguanine (TG) might be more effective than mercaptopurine (MP). The US and UK cooperative groups began randomised thiopurine trials and agreed prospectively to a meta-analysis. All randomised trials of TG versus MP were sought, and data on individual patients were analysed by standard methods. Combining three trials (from US, UK and Germany), the overall event-free survival (EFS) was not significantly improved with TG (odds ratio (OR)=0.89; 95% confidence interval 0.78-1.03). Apparent differences in results between trials may be partly explained by the different types of patients studied. The larger treatment effect reported in males in the US trial was confirmed in the other trials. There was heterogeneity between sex/age subgroups (P=0.001), with significant EFS benefit of TG only observed for males aged

Original languageEnglish (US)
Pages (from-to)953-959
Number of pages7
JournalLeukemia
Volume25
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Thioguanine
Precursor Cell Lymphoblastic Leukemia-Lymphoma
6-Mercaptopurine
Meta-Analysis
Disease-Free Survival
Germany
Odds Ratio
Pharmacology
Confidence Intervals
Therapeutics

Keywords

  • childhood
  • mercaptopurine
  • systematic review
  • thioguanine
  • thiopurine

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine

Cite this

Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia. / Escherich, G.; Richards, S.; Stork, Linda; Vora, A. J.

In: Leukemia, Vol. 25, No. 6, 06.2011, p. 953-959.

Research output: Contribution to journalArticle

Escherich, G. ; Richards, S. ; Stork, Linda ; Vora, A. J. / Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia. In: Leukemia. 2011 ; Vol. 25, No. 6. pp. 953-959.
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