Mesial temporal lobe and memory function in autism spectrum disorder

An exploration of volumetric findings

Haley G. Trontel, Tyler Duffield, Erin D. Bigler, Tracy J. Abildskov, Alyson Froehlich, Molly B.D. Prigge, Brittany G. Travers, Jeffrey S. Anderson, Brandon A. Zielinski, Andrew L. Alexander, Nicholas Lange, Janet E. Lainhart

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Studies have shown that individuals with autism spectrum disorder (ASD) tend to perform significantly below typical developing individuals on standardized measures of memory, even when not significantly different on measures of IQ. The current study sought to examine within ASD whether anatomical correlates of memory performance differed between those with average-to-above-average IQ (AIQ group) and those with low-average to borderline ability (LIQ group) as well as in relations to typically developing comparisons (TDC). Using automated volumetric analyses, we examined regional volume of classic memory areas including the hippocampus, parahippocampal gyrus, entorhinal cortex, and amygdala in an all-male sample AIQ (n = 38) and LIQ (n = 18) individuals with ASD along with 30 typically developing comparisons (TDC). Memory performance was assessed using the Test of Memory and Learning (TOMAL) compared among the groups and then correlated with regional brain volumes. Analyses revealed group differences on almost all facets of memory and learning as assessed by the various subtests of the TOMAL. The three groups did not differ on any region of interest (ROI) memory-related brain volumes. However, significant size-memory function interactions were observed. Negative correlations were found between the volume of the amygdala and composite, verbal, and delayed memory indices for the LIQ ASD group, indicating larger volume related to poorer performance. Implications for general memory functioning and dysfunctional neural connectivity in ASD are discussed.

Original languageEnglish (US)
Pages (from-to)178-192
Number of pages15
JournalJournal of Clinical and Experimental Neuropsychology
Volume37
Issue number2
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Temporal Lobe
Learning
Amygdala
Autism Spectrum Disorder
Repression (Psychology)
Parahippocampal Gyrus
Entorhinal Cortex
Aptitude
Brain
Hippocampus

Keywords

  • Autism spectrum disorders
  • Magnetic resonance imaging.
  • Memory
  • Neurodevelopmental disorders

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

Cite this

Mesial temporal lobe and memory function in autism spectrum disorder : An exploration of volumetric findings. / Trontel, Haley G.; Duffield, Tyler; Bigler, Erin D.; Abildskov, Tracy J.; Froehlich, Alyson; Prigge, Molly B.D.; Travers, Brittany G.; Anderson, Jeffrey S.; Zielinski, Brandon A.; Alexander, Andrew L.; Lange, Nicholas; Lainhart, Janet E.

In: Journal of Clinical and Experimental Neuropsychology, Vol. 37, No. 2, 01.01.2015, p. 178-192.

Research output: Contribution to journalArticle

Trontel, HG, Duffield, T, Bigler, ED, Abildskov, TJ, Froehlich, A, Prigge, MBD, Travers, BG, Anderson, JS, Zielinski, BA, Alexander, AL, Lange, N & Lainhart, JE 2015, 'Mesial temporal lobe and memory function in autism spectrum disorder: An exploration of volumetric findings', Journal of Clinical and Experimental Neuropsychology, vol. 37, no. 2, pp. 178-192. https://doi.org/10.1080/13803395.2014.997677
Trontel, Haley G. ; Duffield, Tyler ; Bigler, Erin D. ; Abildskov, Tracy J. ; Froehlich, Alyson ; Prigge, Molly B.D. ; Travers, Brittany G. ; Anderson, Jeffrey S. ; Zielinski, Brandon A. ; Alexander, Andrew L. ; Lange, Nicholas ; Lainhart, Janet E. / Mesial temporal lobe and memory function in autism spectrum disorder : An exploration of volumetric findings. In: Journal of Clinical and Experimental Neuropsychology. 2015 ; Vol. 37, No. 2. pp. 178-192.
@article{7dce75ba39294b5db4b56a88e4a5a087,
title = "Mesial temporal lobe and memory function in autism spectrum disorder: An exploration of volumetric findings",
abstract = "Studies have shown that individuals with autism spectrum disorder (ASD) tend to perform significantly below typical developing individuals on standardized measures of memory, even when not significantly different on measures of IQ. The current study sought to examine within ASD whether anatomical correlates of memory performance differed between those with average-to-above-average IQ (AIQ group) and those with low-average to borderline ability (LIQ group) as well as in relations to typically developing comparisons (TDC). Using automated volumetric analyses, we examined regional volume of classic memory areas including the hippocampus, parahippocampal gyrus, entorhinal cortex, and amygdala in an all-male sample AIQ (n = 38) and LIQ (n = 18) individuals with ASD along with 30 typically developing comparisons (TDC). Memory performance was assessed using the Test of Memory and Learning (TOMAL) compared among the groups and then correlated with regional brain volumes. Analyses revealed group differences on almost all facets of memory and learning as assessed by the various subtests of the TOMAL. The three groups did not differ on any region of interest (ROI) memory-related brain volumes. However, significant size-memory function interactions were observed. Negative correlations were found between the volume of the amygdala and composite, verbal, and delayed memory indices for the LIQ ASD group, indicating larger volume related to poorer performance. Implications for general memory functioning and dysfunctional neural connectivity in ASD are discussed.",
keywords = "Autism spectrum disorders, Magnetic resonance imaging., Memory, Neurodevelopmental disorders",
author = "Trontel, {Haley G.} and Tyler Duffield and Bigler, {Erin D.} and Abildskov, {Tracy J.} and Alyson Froehlich and Prigge, {Molly B.D.} and Travers, {Brittany G.} and Anderson, {Jeffrey S.} and Zielinski, {Brandon A.} and Alexander, {Andrew L.} and Nicholas Lange and Lainhart, {Janet E.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1080/13803395.2014.997677",
language = "English (US)",
volume = "37",
pages = "178--192",
journal = "Journal of Clinical and Experimental Neuropsychology",
issn = "0168-8634",
publisher = "Psychology Press Ltd",
number = "2",

}

TY - JOUR

T1 - Mesial temporal lobe and memory function in autism spectrum disorder

T2 - An exploration of volumetric findings

AU - Trontel, Haley G.

AU - Duffield, Tyler

AU - Bigler, Erin D.

AU - Abildskov, Tracy J.

AU - Froehlich, Alyson

AU - Prigge, Molly B.D.

AU - Travers, Brittany G.

AU - Anderson, Jeffrey S.

AU - Zielinski, Brandon A.

AU - Alexander, Andrew L.

AU - Lange, Nicholas

AU - Lainhart, Janet E.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Studies have shown that individuals with autism spectrum disorder (ASD) tend to perform significantly below typical developing individuals on standardized measures of memory, even when not significantly different on measures of IQ. The current study sought to examine within ASD whether anatomical correlates of memory performance differed between those with average-to-above-average IQ (AIQ group) and those with low-average to borderline ability (LIQ group) as well as in relations to typically developing comparisons (TDC). Using automated volumetric analyses, we examined regional volume of classic memory areas including the hippocampus, parahippocampal gyrus, entorhinal cortex, and amygdala in an all-male sample AIQ (n = 38) and LIQ (n = 18) individuals with ASD along with 30 typically developing comparisons (TDC). Memory performance was assessed using the Test of Memory and Learning (TOMAL) compared among the groups and then correlated with regional brain volumes. Analyses revealed group differences on almost all facets of memory and learning as assessed by the various subtests of the TOMAL. The three groups did not differ on any region of interest (ROI) memory-related brain volumes. However, significant size-memory function interactions were observed. Negative correlations were found between the volume of the amygdala and composite, verbal, and delayed memory indices for the LIQ ASD group, indicating larger volume related to poorer performance. Implications for general memory functioning and dysfunctional neural connectivity in ASD are discussed.

AB - Studies have shown that individuals with autism spectrum disorder (ASD) tend to perform significantly below typical developing individuals on standardized measures of memory, even when not significantly different on measures of IQ. The current study sought to examine within ASD whether anatomical correlates of memory performance differed between those with average-to-above-average IQ (AIQ group) and those with low-average to borderline ability (LIQ group) as well as in relations to typically developing comparisons (TDC). Using automated volumetric analyses, we examined regional volume of classic memory areas including the hippocampus, parahippocampal gyrus, entorhinal cortex, and amygdala in an all-male sample AIQ (n = 38) and LIQ (n = 18) individuals with ASD along with 30 typically developing comparisons (TDC). Memory performance was assessed using the Test of Memory and Learning (TOMAL) compared among the groups and then correlated with regional brain volumes. Analyses revealed group differences on almost all facets of memory and learning as assessed by the various subtests of the TOMAL. The three groups did not differ on any region of interest (ROI) memory-related brain volumes. However, significant size-memory function interactions were observed. Negative correlations were found between the volume of the amygdala and composite, verbal, and delayed memory indices for the LIQ ASD group, indicating larger volume related to poorer performance. Implications for general memory functioning and dysfunctional neural connectivity in ASD are discussed.

KW - Autism spectrum disorders

KW - Magnetic resonance imaging.

KW - Memory

KW - Neurodevelopmental disorders

UR - http://www.scopus.com/inward/record.url?scp=84924346273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924346273&partnerID=8YFLogxK

U2 - 10.1080/13803395.2014.997677

DO - 10.1080/13803395.2014.997677

M3 - Article

VL - 37

SP - 178

EP - 192

JO - Journal of Clinical and Experimental Neuropsychology

JF - Journal of Clinical and Experimental Neuropsychology

SN - 0168-8634

IS - 2

ER -