Mesenchymal chondrosarcoma: A report of 17 cases

A. R. Harwood, Joseph (Ivan) Krajbich, V. L. Fornasier

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Mesenchymal chondrosarcoma is a rare, amost uniformally lethal variant of chondrosarcoma which has been regarded as resistant to chemotherapy and radiotherapy. Seventeen cases are reported; 14 are dead of tumor or still alive with disease; eight of the 14 died less than one year after treatment, predominately of distant metastatic disease. This confirms previous reports of the highly aggressive nature of mesenchymal chondrosarcoma. Although surgery is regarded as the major method of treating the primary disease, it has limitations because many tumors cannot be adequately removed owing to location or extension to unresectable sites. It was found that such tumors respond to irradiation and that a combination of chemotherapy and radiotherapy should be used in unresectable tumors or those resected with inadequate margins. Adjuvant chemotherapy is advised in all cases treated with radical surgical excision. Unfavorable prognostic factors in mesenchymal chondrosarcoma are pain as a presenting symptom and a central rather than a peripheral limb location.

Original languageEnglish (US)
Pages (from-to)144-148
Number of pages5
JournalClinical Orthopaedics and Related Research
VolumeNO.158
StatePublished - 1981
Externally publishedYes

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Mesenchymal Chondrosarcoma
Neoplasms
Radiotherapy
Chondrosarcoma
Adjuvant Chemotherapy
Combination Drug Therapy
Extremities
Drug Therapy
Pain

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Mesenchymal chondrosarcoma : A report of 17 cases. / Harwood, A. R.; Krajbich, Joseph (Ivan); Fornasier, V. L.

In: Clinical Orthopaedics and Related Research, Vol. NO.158, 1981, p. 144-148.

Research output: Contribution to journalArticle

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