Menstrual cycle and sex affect hemodynamic responses to combined orthostatic and heat stress

Jessica R. Meendering, Britta N. Torgrimson, Belinda McCully, John R. Halliwill, Christopher T. Minson

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Women have decreased orthostatic tolerance compared with men, and anecdotal evidence suggests women are more susceptible to orthostatic intolerance in warm environments. Because estrogen and progesterone affect numerous physiological variables that may alter orthostatic tolerance, the purpose of our study was to compare orthostatic tolerance across the menstrual cycle phases in women during combined orthostatic and heat stress and to compare these data with those of men. Eight normally menstruating women and eight males (22 ± 4.0 and 23 ± 3.5 yr, respectively) completed the protocol. Women were studied during their early follicular (EF), ovulatory (OV), and midluteal (ML) phases. Men were studied twice within 2-4 wk. Heart rate, cardiac output, blood pressure, core temperature (Tc), and cutaneous vascular conductance (CVC) were measured during three head-up tilt tests, consisting of two tilts in the thermoneutral condition and one tilt after a 0.5°C rise in Tc. There was no difference in orthostatic tolerance across the menstrual cycle phases, despite higher CVC in the ML phase after heating (EF, 42.3 ± 4.8; OV, 40.1 ± 3.7; ML, 57.5 ± 4.5; P < 0.05). Orthostatic tolerance in the heat was greater in men than women (P < 0.05). These data suggest that although many physiological variables associated with blood pressure regulation fluctuate during the menstrual cycle, orthostatic tolerance in the heat remains unchanged. Additionally, our data support a clear sex difference in orthostatic tolerance and extend upon previous data to show that the sex difference in the heat is not attributable to fluctuating hormone profiles during the menstrual cycle.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume289
Issue number2 58-2
DOIs
StatePublished - Aug 2005
Externally publishedYes

Fingerprint

Menstrual Cycle
Hot Temperature
Hemodynamics
Sex Characteristics
Blood Vessels
Orthostatic Intolerance
Blood Pressure
Skin
Cardiac Output
Heating
Progesterone
Estrogens
Heart Rate
Head
Hormones
Temperature

Keywords

  • Blood pressure
  • Estrogen
  • Progesterone

ASJC Scopus subject areas

  • Physiology

Cite this

Menstrual cycle and sex affect hemodynamic responses to combined orthostatic and heat stress. / Meendering, Jessica R.; Torgrimson, Britta N.; McCully, Belinda; Halliwill, John R.; Minson, Christopher T.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 289, No. 2 58-2, 08.2005.

Research output: Contribution to journalArticle

Meendering, Jessica R. ; Torgrimson, Britta N. ; McCully, Belinda ; Halliwill, John R. ; Minson, Christopher T. / Menstrual cycle and sex affect hemodynamic responses to combined orthostatic and heat stress. In: American Journal of Physiology - Heart and Circulatory Physiology. 2005 ; Vol. 289, No. 2 58-2.
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