Menopause and tear function: The influence of prolactin and sex hormones on human tear production

William Mathers, Dale Stovall, James A. Lane, M. Bridget Zimmerman, Susan Johnson

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Purpose. The onset of dry eye is very common during menopause and may result from the loss of hormonal support. The purpose of this study was to assess the effect that changes in sex hormone and prolactin levels have on tear function in premenopausal and menopausal woman. Methods. Women between the ages of 30 and 60 were solicited to participate in a study concerning menopause and tear function. One-hundred and ten women were given tear function tests (osmolarity, tear volume, tear flow, Schirmer's test) and serum levels were measured for total testosterone, estradiol, prolactin, and follicle stimulating hormone. Results. For all women on hormone replacement therapy, we found a strong negative correlation between serum prolactin level and tear function. For women in menopause, total testosterone correlated positively with tear function, whereas for premenopausal women there was a negative correlation between total testosterone and tear function. Serum estradiol levels correlated positively with tear function for women 30-39 years of age, whereas for menopausal women the correlation was negative. Conclusions. This is the first demonstration in humans that tear production is correlated with serum prolactin and sex hormone levels prior to and during the menopause.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalCornea
Volume17
Issue number4
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Gonadal Steroid Hormones
Menopause
Tears
Prolactin
Testosterone
Serum
Estradiol
Hormone Replacement Therapy
Follicle Stimulating Hormone
Osmolar Concentration

Keywords

  • Dry eye
  • Estradiol Testosterone
  • Lacrimal gland
  • Menopause
  • Prolactin
  • Tears

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Menopause and tear function : The influence of prolactin and sex hormones on human tear production. / Mathers, William; Stovall, Dale; Lane, James A.; Zimmerman, M. Bridget; Johnson, Susan.

In: Cornea, Vol. 17, No. 4, 1998, p. 353-358.

Research output: Contribution to journalArticle

Mathers, William ; Stovall, Dale ; Lane, James A. ; Zimmerman, M. Bridget ; Johnson, Susan. / Menopause and tear function : The influence of prolactin and sex hormones on human tear production. In: Cornea. 1998 ; Vol. 17, No. 4. pp. 353-358.
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