Men, bone and estrogen: Unresolved issues

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Gonadal function has long been known to be important for skeletal health in men. Prepubertal hypogonadism is clearly associated with impairment in peak bone mass development and adult-onset hypogonadism with accelerated bone loss. Gonadal failure results in deficits in both androgen and estrogen action, but traditionally androgens were assumed to have the most important skeletal effect in men. Recently that model has been reconsidered as a variety of kinds of evidence have appeared to document a critical role for estrogen in bone physiology. As a result of this fresh perspective a host of interesting new dilemmas and hypotheses are being examined, including those related to the mechanisms of sex steroid action in bone, the origins of gender differences in skeletal morphology and physiology, and the role of estrogen in diagnostic and therapeutic strategies in men with metabolic bone disorders.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalOsteoporosis International
Volume14
Issue number2
DOIs
StatePublished - 2003

Fingerprint

Estrogens
Bone and Bones
Hypogonadism
Androgens
Men's Health
Bone Development
Steroids
Therapeutics

Keywords

  • Aromatase
  • Estrogen
  • Estrogen receptor
  • Osteoporosis, male
  • Skeleton

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Men, bone and estrogen : Unresolved issues. / Orwoll, Eric.

In: Osteoporosis International, Vol. 14, No. 2, 2003, p. 93-98.

Research output: Contribution to journalArticle

@article{da9d86e272fc40b9bd034e0462f0d54b,
title = "Men, bone and estrogen: Unresolved issues",
abstract = "Gonadal function has long been known to be important for skeletal health in men. Prepubertal hypogonadism is clearly associated with impairment in peak bone mass development and adult-onset hypogonadism with accelerated bone loss. Gonadal failure results in deficits in both androgen and estrogen action, but traditionally androgens were assumed to have the most important skeletal effect in men. Recently that model has been reconsidered as a variety of kinds of evidence have appeared to document a critical role for estrogen in bone physiology. As a result of this fresh perspective a host of interesting new dilemmas and hypotheses are being examined, including those related to the mechanisms of sex steroid action in bone, the origins of gender differences in skeletal morphology and physiology, and the role of estrogen in diagnostic and therapeutic strategies in men with metabolic bone disorders.",
keywords = "Aromatase, Estrogen, Estrogen receptor, Osteoporosis, male, Skeleton",
author = "Eric Orwoll",
year = "2003",
doi = "10.1007/s00198-002-1332-9",
language = "English (US)",
volume = "14",
pages = "93--98",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "2",

}

TY - JOUR

T1 - Men, bone and estrogen

T2 - Unresolved issues

AU - Orwoll, Eric

PY - 2003

Y1 - 2003

N2 - Gonadal function has long been known to be important for skeletal health in men. Prepubertal hypogonadism is clearly associated with impairment in peak bone mass development and adult-onset hypogonadism with accelerated bone loss. Gonadal failure results in deficits in both androgen and estrogen action, but traditionally androgens were assumed to have the most important skeletal effect in men. Recently that model has been reconsidered as a variety of kinds of evidence have appeared to document a critical role for estrogen in bone physiology. As a result of this fresh perspective a host of interesting new dilemmas and hypotheses are being examined, including those related to the mechanisms of sex steroid action in bone, the origins of gender differences in skeletal morphology and physiology, and the role of estrogen in diagnostic and therapeutic strategies in men with metabolic bone disorders.

AB - Gonadal function has long been known to be important for skeletal health in men. Prepubertal hypogonadism is clearly associated with impairment in peak bone mass development and adult-onset hypogonadism with accelerated bone loss. Gonadal failure results in deficits in both androgen and estrogen action, but traditionally androgens were assumed to have the most important skeletal effect in men. Recently that model has been reconsidered as a variety of kinds of evidence have appeared to document a critical role for estrogen in bone physiology. As a result of this fresh perspective a host of interesting new dilemmas and hypotheses are being examined, including those related to the mechanisms of sex steroid action in bone, the origins of gender differences in skeletal morphology and physiology, and the role of estrogen in diagnostic and therapeutic strategies in men with metabolic bone disorders.

KW - Aromatase

KW - Estrogen

KW - Estrogen receptor

KW - Osteoporosis, male

KW - Skeleton

UR - http://www.scopus.com/inward/record.url?scp=0347630358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347630358&partnerID=8YFLogxK

U2 - 10.1007/s00198-002-1332-9

DO - 10.1007/s00198-002-1332-9

M3 - Article

C2 - 12730776

AN - SCOPUS:0347630358

VL - 14

SP - 93

EP - 98

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 2

ER -