Memory, mood, and vitamin d in persons with parkinson's disease

Amie Peterson, Charles Murchison, Cyrus Zabetian, James B. Leverenz, G. Stennis Watson, Thomas Montine, Natasha Carney, Gene Bowman, Karen Edwards, Joseph Quinn

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Research in recent years has suggested a role of vitamin D in the central nervous system. The final converting enzyme and the vitamin D receptor are found throughout the human brain. From animal studies vitamin D appears important in neurodevelopment, up-regulation of neurotrophic factors, stabilization of mitochondrial function, and antioxidation. Objective: To examine the relationship between serum vitamin D and neuropsychiatric function in persons with Parkinson's disease (PD). Methods: This is an add-on study to a longitudinal study following neuropsychiatric function in persons with PD. Baseline neuropsychiatric performance and serum 25-hydroxyvitamin D were examined for 286 participants with PD. Measures of global cognitive function (MMSE, MOCA, Mattis Dementia Scale), verbal memory (Hopkins Verbal Learning Test), fluency (animals, vegetables, and FAS words), visuospatial function (Benton Line Orientation), executive function (Trails Making Test and Digit-Symbol Substitution), PD severity (Hoehn & Yahr and Unified Parkinson's Disease Rating Scale) and depression (Geriatric Depression Scale (GDS)) were administered. Multivariate linear regression assessed the association between vitamin D concentration and neuropsychiatric function, in the entire cohort as well as the non-demented and demented subsets. Results: Using a multivariate model, higher vitamin D concentrations were associated with better performance on numerous neuropsychiatric tests in the non-demented subset of the cohort. Significant associations were specifically found between vitamin D concentration and verbal fluency and verbal memory (t = 4.31, p <0.001 and t = 3.04, p = 0.0083). Vitamin D concentrations also correlated with depression scores (t = -3.08, p = 0.0083) in the non-demented subset. Conclusions: Higher plasma vitamin D is associated with better cognition and better mood in this sample of PD patients without dementia. Determination of causation will require a vitamin D intervention study.

Original languageEnglish (US)
Pages (from-to)547-555
Number of pages9
JournalJournal of Parkinson's Disease
Volume3
Issue number4
DOIs
StatePublished - 2013

Fingerprint

Vitamin D
Vitamins
Parkinson Disease
Depression
Cognition
Dementia
Methylenebis(chloroaniline)
Trail Making Test
Verbal Learning
Calcitriol Receptors
Executive Function
Nerve Growth Factors
Serum
Causality
Geriatrics
Vegetables
Longitudinal Studies
Linear Models
Up-Regulation
Central Nervous System

Keywords

  • Cognition
  • Dementia
  • Depression
  • Parkinson's disease
  • Vitamin D

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Memory, mood, and vitamin d in persons with parkinson's disease. / Peterson, Amie; Murchison, Charles; Zabetian, Cyrus; Leverenz, James B.; Watson, G. Stennis; Montine, Thomas; Carney, Natasha; Bowman, Gene; Edwards, Karen; Quinn, Joseph.

In: Journal of Parkinson's Disease, Vol. 3, No. 4, 2013, p. 547-555.

Research output: Contribution to journalArticle

Peterson, A, Murchison, C, Zabetian, C, Leverenz, JB, Watson, GS, Montine, T, Carney, N, Bowman, G, Edwards, K & Quinn, J 2013, 'Memory, mood, and vitamin d in persons with parkinson's disease', Journal of Parkinson's Disease, vol. 3, no. 4, pp. 547-555. https://doi.org/10.3233/JPD-130206
Peterson, Amie ; Murchison, Charles ; Zabetian, Cyrus ; Leverenz, James B. ; Watson, G. Stennis ; Montine, Thomas ; Carney, Natasha ; Bowman, Gene ; Edwards, Karen ; Quinn, Joseph. / Memory, mood, and vitamin d in persons with parkinson's disease. In: Journal of Parkinson's Disease. 2013 ; Vol. 3, No. 4. pp. 547-555.
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AU - Peterson, Amie

AU - Murchison, Charles

AU - Zabetian, Cyrus

AU - Leverenz, James B.

AU - Watson, G. Stennis

AU - Montine, Thomas

AU - Carney, Natasha

AU - Bowman, Gene

AU - Edwards, Karen

AU - Quinn, Joseph

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