Memory formation and retention are affected in adult miR-132/212 knockout mice

Julia Hernandez-Rapp, Pascal Y. Smith, Mohammed Filali, Claudia Goupil, Emmanuel Planel, Stephen T. Magill, Richard Goodman, Sébastien S. Hébert

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The miR-132/212 family is thought to play an important role in neural function and plasticity, while its misregulation has been observed in various neurodegenerative disorders. In this study, we analyzed 6-month-old miR-132/212 knockout mice in a battery of cognitive and non-cognitive behavioral tests. No significant changes were observed in reflexes and basic sensorimotor functions as determined by the SHIRPA primary screen. Accordingly, miR-132/212 knockout mice did not differ from wild-type controls in general locomotor activity in an open-field test. Furthermore, no significant changes of anxiety were measured in an elevated plus maze task. However, the mutant mice showed retention phase defects in a novel object recognition test and in the T-water maze. Moreover, the learning and probe phases in the Barnes maze were clearly altered in knockout mice when compared to controls. Finally, changes in BDNF, CREB, and MeCP2 were identified in the miR-132/212-deficient mice, providing a potential mechanism for promoting memory loss. Taken together, these results further strengthen the role of miR-132/212 in memory formation and retention, and shed light on the potential consequences of its deregulation in neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)15-26
Number of pages12
JournalBehavioural Brain Research
Volume287
DOIs
StatePublished - Jul 1 2015

Fingerprint

Knockout Mice
Neurodegenerative Diseases
Neuronal Plasticity
Brain-Derived Neurotrophic Factor
Memory Disorders
Locomotion
Reflex
Anxiety
Learning
Water
Retention (Psychology)

Keywords

  • Cognitive deficit
  • CREB, Alzheimer's disease
  • Dementia
  • MiR-132
  • MiR-212

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Hernandez-Rapp, J., Smith, P. Y., Filali, M., Goupil, C., Planel, E., Magill, S. T., ... Hébert, S. S. (2015). Memory formation and retention are affected in adult miR-132/212 knockout mice. Behavioural Brain Research, 287, 15-26. https://doi.org/10.1016/j.bbr.2015.03.032

Memory formation and retention are affected in adult miR-132/212 knockout mice. / Hernandez-Rapp, Julia; Smith, Pascal Y.; Filali, Mohammed; Goupil, Claudia; Planel, Emmanuel; Magill, Stephen T.; Goodman, Richard; Hébert, Sébastien S.

In: Behavioural Brain Research, Vol. 287, 01.07.2015, p. 15-26.

Research output: Contribution to journalArticle

Hernandez-Rapp, J, Smith, PY, Filali, M, Goupil, C, Planel, E, Magill, ST, Goodman, R & Hébert, SS 2015, 'Memory formation and retention are affected in adult miR-132/212 knockout mice', Behavioural Brain Research, vol. 287, pp. 15-26. https://doi.org/10.1016/j.bbr.2015.03.032
Hernandez-Rapp J, Smith PY, Filali M, Goupil C, Planel E, Magill ST et al. Memory formation and retention are affected in adult miR-132/212 knockout mice. Behavioural Brain Research. 2015 Jul 1;287:15-26. https://doi.org/10.1016/j.bbr.2015.03.032
Hernandez-Rapp, Julia ; Smith, Pascal Y. ; Filali, Mohammed ; Goupil, Claudia ; Planel, Emmanuel ; Magill, Stephen T. ; Goodman, Richard ; Hébert, Sébastien S. / Memory formation and retention are affected in adult miR-132/212 knockout mice. In: Behavioural Brain Research. 2015 ; Vol. 287. pp. 15-26.
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