Membranes, Methylation and Lithium Responsive Psychoses

R. Hitzemann, J. Hirschowitz, A. Panini, C. Mark, D. Garver

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Data are presented showing that the erythrocyte ghost membranes of lithium-responsive and non-responsive schizophrenic-like patients are different from control membranes. In both groups of patients there was a significant decrement of phosphatidylcholine (PC) which was largely compenstated for by an increase in sphingomyelin. The decrement in PC may in part be associated with a decrease in phospholipid methylation which converts phosphatidylethanolmine (PE) to PC. Interestingly, in the lithium-responsive but not the non-responsive patients, lithium stimulates methylation activity. This stimulation may affect a variety of membrane functions, e.g. adenyl cyclase activity, which would be involved in lithium's therapeutic actions.

Original languageEnglish (US)
Pages (from-to)153-162
Number of pages10
JournalNutrition and Health
Volume3
Issue number3
DOIs
StatePublished - Jul 1984

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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