Membrane-permeant, bioactivatable derivatives of inositol polyphosphates and phosphoinositides

Carsten Schultz, Marco T. Rudolf, Hartmut H. Gillandt, Alexis E. Traynor-Kaplan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The extracellular application of membrane-permeant, bioactivatable derivatives of myo-inositol 1,4,5-trisphosphate and phosphatidyl-myo-inositol 3,4,5-trisphosphate to living cells mimicked the intracellular action of these second messengers, such as elevation of intracellular Ca2+-levels in PC12 cells and inhibition of calcium-mediated chloride secretion in T84 cells, respectively. 3,6-Di-O-butyryl-myo-inositol 1,2,4,5-tetrakisphosphate hexakis(acetoxy methyl) ester and 1',2'-dipalmitoyl-6-O-butyryl-phosphatidyl-myo-inositol 3,4,5-trisphosphate heptakis(acetoxymethyl) ester were prepared by total synthesis.

Original languageEnglish (US)
Pages (from-to)232-243
Number of pages12
JournalACS Symposium Series
Volume718
StatePublished - 1999
Externally publishedYes

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Polyphosphates
Inositol
Phosphatidylinositols
Esters
Derivatives
Membranes
Calcium chloride
Inositol 1,4,5-Trisphosphate
Second Messenger Systems
Cells
inositol 3,4,5-trisphosphate
inositol-1,2,4,5-tetrakisphosphate

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Schultz, C., Rudolf, M. T., Gillandt, H. H., & Traynor-Kaplan, A. E. (1999). Membrane-permeant, bioactivatable derivatives of inositol polyphosphates and phosphoinositides. ACS Symposium Series, 718, 232-243.

Membrane-permeant, bioactivatable derivatives of inositol polyphosphates and phosphoinositides. / Schultz, Carsten; Rudolf, Marco T.; Gillandt, Hartmut H.; Traynor-Kaplan, Alexis E.

In: ACS Symposium Series, Vol. 718, 1999, p. 232-243.

Research output: Contribution to journalArticle

Schultz, Carsten ; Rudolf, Marco T. ; Gillandt, Hartmut H. ; Traynor-Kaplan, Alexis E. / Membrane-permeant, bioactivatable derivatives of inositol polyphosphates and phosphoinositides. In: ACS Symposium Series. 1999 ; Vol. 718. pp. 232-243.
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