The extracellular application of membrane-permeant, bioactivatable derivatives of myo-inositol 1,4,5-trisphosphate and phosphatidyl-myo-inositol 3,4,5-trisphosphate to living cells mimicked the intracellular action of these second messengers, such as elevation of intracellular Ca2+-levels in PC12 cells and inhibition of calcium-mediated chloride secretion in T84 cells, respectively. 3,6-Di-O-butyryl-myo-inositol 1,2,4,5-tetrakisphosphate hexakis(acetoxy methyl) ester and 1',2'-dipalmitoyl-6-O-butyryl-phosphatidyl-myo-inositol 3,4,5-trisphosphate heptakis(acetoxymethyl) ester were prepared by total synthesis.
|Original language||English (US)|
|Number of pages||12|
|Journal||ACS Symposium Series|
|State||Published - Dec 1 1999|
ASJC Scopus subject areas
- Chemical Engineering(all)