Membrane-permeant 3-OH-phosphorylated phosphoinositide derivatives

Carlo Dinkel, Mark Moody, Alexis Traynor-Kaplan, Carsten Schultz

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

A crucial role in the regulation of epithelial chloride secretion is played by the phosphoinositide PtdIns(3,4,5)P3. Membrane-permeant derivatives of this and other naturally occurring phosphoinositides have been synthesized. These derivatives, which can be bioactivated, were used in investigations on nasal epithelia of patients suffering from cystic fibrosis (see general scheme).

Original languageEnglish (US)
Pages (from-to)3004-3008
Number of pages5
JournalAngewandte Chemie - International Edition
Volume40
Issue number16
DOIs
StatePublished - Aug 17 2001

Keywords

  • Cyclitols
  • Cystic fibrosis
  • Phosphoinositides
  • Secretion
  • Signal transduction

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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