Membrane-initiated signaling of estrogen in the brain

Oline K. Rønnekleiv, Anna Malyala, Martin J. Kelly

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


It is well known that many of the actions of estrogen in the central nervous system are mediated via intracellular receptor/transcription factors that interact with steroid response elements on target genes. However, there now exists compelling evidence for membrane steroid receptors for estrogen in hypothalamic and other brain neurons. It is not well understood how estrogen signals via membrane receptors, and how these signals influence not only membrane excitability but also gene transcription in neurons. Indeed, it has been known for some time that estrogen can rapidly alter neuronal activity within seconds, indicating that some cellular effects can occur via membrane-delimited events. In addition, estrogen can affect second messenger systems including calcium mobilization and a plethora of kinases to alter cell signaling. Therefore, this review considers our current knowledge of rapid membrane-initiated and intracellular signaling by estrogen in the brain, and the nature of receptors involved and how they contribute to homeostatic functions.

Original languageEnglish (US)
Pages (from-to)165-177
Number of pages13
JournalSeminars in Reproductive Medicine
Issue number3
StatePublished - May 2007


  • G protein-coupled receptor
  • Gαq
  • K channels
  • pCREB

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)


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