TY - JOUR
T1 - Membrane-initiated estrogen signaling in hypothalamic neurons
AU - Kelly, Martin J.
AU - Rønnekleiv, Oline K.
N1 - Funding Information:
The authors thank members of their laboratories who contributed to the work described herein, especially Dr. Jian Qiu, Dr. Chunguang Zhang, Troy A. Roepke, Dr. Anna Malyala and Dr. Ms. Martha A. Bosch. Also, special thanks to Ms. Martha A. Bosch for her skilled assistance with the illustrations and manuscript preparation. The work from the authors’ laboratories was supported by PHS grants NS 43330, NS 38809 and DK 68098.
PY - 2008/8/13
Y1 - 2008/8/13
N2 - It is well known that many of the actions of 17β-estradiol (E2) in the central nervous system are mediated via intracellular receptor/transcription factors that interact with steroid response elements on target genes. However, there is compelling evidence for membrane steroid receptors for estrogen in hypothalamic and other brain neurons. But it is not well understood how estrogen signals via membrane receptors, and how these signals impact not only membrane excitability but also gene transcription in neurons. Indeed, it has been known for sometime that E2 can rapidly alter neuronal activity within seconds, indicating that some cellular effects can occur via membrane delimited events. In addition, E2 can affect second messenger systems including calcium mobilization and a plethora of kinases to alter cell signaling. Therefore, this review will consider our current knowledge of rapid membrane-initiated and intracellular signaling by E2 in the hypothalamus, the nature of receptors involved and how they contribute to homeostatic functions.
AB - It is well known that many of the actions of 17β-estradiol (E2) in the central nervous system are mediated via intracellular receptor/transcription factors that interact with steroid response elements on target genes. However, there is compelling evidence for membrane steroid receptors for estrogen in hypothalamic and other brain neurons. But it is not well understood how estrogen signals via membrane receptors, and how these signals impact not only membrane excitability but also gene transcription in neurons. Indeed, it has been known for sometime that E2 can rapidly alter neuronal activity within seconds, indicating that some cellular effects can occur via membrane delimited events. In addition, E2 can affect second messenger systems including calcium mobilization and a plethora of kinases to alter cell signaling. Therefore, this review will consider our current knowledge of rapid membrane-initiated and intracellular signaling by E2 in the hypothalamus, the nature of receptors involved and how they contribute to homeostatic functions.
KW - ERα
KW - ERβ
KW - G protein-coupled receptor (GPCR)
KW - Membrane estrogen receptor that is a GPCR (mER)
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U2 - 10.1016/j.mce.2008.04.014
DO - 10.1016/j.mce.2008.04.014
M3 - Review article
C2 - 18538919
AN - SCOPUS:48049104849
SN - 0303-7207
VL - 290
SP - 14
EP - 23
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-2
ER -