Membrane-initiated effects of estrogen in the central nervous system

O. K. Rnnekleiv, M. J. Kelly

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is well known that many of the actions of estrogen in the central nervous system are mediated via intracellular receptor/transcription factors that interact with steroid response elements on target genes. However, there now exists compelling evidence for membrane steroid receptors for estrogen in hypothalamic and other brain neurons. But, it is not well understood how estrogen signals via membrane receptors, and how these signals impact not only membrane excitability but also gene transcription in neurons. Indeed, it has been known for sometime that estrogen can rapidly alter neuronal activity within seconds, indicating that some cellular effects can occur via membrane delimited events. In addition, estrogen can affect second messenger systems, including calcium mobilization and a plethora of kinases to alter cell signaling. Therefore, this chapter considers our current knowledge of rapid membrane-initiated and intracellular signaling by estrogen in the brain, the nature of receptors involved, and how they contribute to homeostatic functions.

Original languageEnglish (US)
Title of host publicationHormones, Brain and Behavior Online
PublisherElsevier Inc.
Pages1099-1122
Number of pages24
ISBN (Print)9780080887838
DOIs
StatePublished - Jan 1 2009

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Keywords

  • ERα
  • ERβ
  • GIRK channels
  • GPCR
  • GnRH
  • MAPK
  • MER
  • PCREB
  • PI3K
  • PKA
  • PKC
  • POMC
  • μ-Opioid receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rnnekleiv, O. K., & Kelly, M. J. (2009). Membrane-initiated effects of estrogen in the central nervous system. In Hormones, Brain and Behavior Online (pp. 1099-1122). Elsevier Inc.. https://doi.org/10.1016/B978-008088783-8.00032-2