Abstract
Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ERα and ERβ, and a number of putative membrane ERs, including ERα, ERβ, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and physiology has been discovered. In other cases, the identity or the function remains to be elucidated. This mini-review attempts to synthesize our understanding of 17β-estradiol membrane signaling within hypothalamic circuits involved in homeostatic functions, focusing on reproduction and energy balance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-110 |
| Number of pages | 8 |
| Journal | Neuroendocrinology |
| Volume | 96 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 2012 |
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Keywords
- 17β-estradiol
- Estrogen receptor alpha
- Estrogen receptor beta
- Gαq-coupled membrane estrogen receptor
- Gonadotropin-releasing hormone neuron
- GPR30 (GPER1)
- mGluR1 receptor
- Proopiomelanocortin neuron
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience
Cite this
Membrane estrogen receptor regulation of hypothalamic function. / Micevych, Paul E.; Kelly, Martin.
In: Neuroendocrinology, Vol. 96, No. 2, 09.2012, p. 103-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Membrane estrogen receptor regulation of hypothalamic function
AU - Micevych, Paul E.
AU - Kelly, Martin
PY - 2012/9
Y1 - 2012/9
N2 - Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ERα and ERβ, and a number of putative membrane ERs, including ERα, ERβ, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and physiology has been discovered. In other cases, the identity or the function remains to be elucidated. This mini-review attempts to synthesize our understanding of 17β-estradiol membrane signaling within hypothalamic circuits involved in homeostatic functions, focusing on reproduction and energy balance.
AB - Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ERα and ERβ, and a number of putative membrane ERs, including ERα, ERβ, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and physiology has been discovered. In other cases, the identity or the function remains to be elucidated. This mini-review attempts to synthesize our understanding of 17β-estradiol membrane signaling within hypothalamic circuits involved in homeostatic functions, focusing on reproduction and energy balance.
KW - 17β-estradiol
KW - Estrogen receptor alpha
KW - Estrogen receptor beta
KW - Gαq-coupled membrane estrogen receptor
KW - Gonadotropin-releasing hormone neuron
KW - GPR30 (GPER1)
KW - mGluR1 receptor
KW - Proopiomelanocortin neuron
UR - http://www.scopus.com/inward/record.url?scp=84866552268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866552268&partnerID=8YFLogxK
U2 - 10.1159/000338400
DO - 10.1159/000338400
M3 - Article
C2 - 22538318
AN - SCOPUS:84866552268
VL - 96
SP - 103
EP - 110
JO - Neuroendocrinology
JF - Neuroendocrinology
SN - 0028-3835
IS - 2
ER -