Membrane estrogen receptor regulation of hypothalamic function

Paul E. Micevych, Martin J. Kelly

Research output: Contribution to journalArticle

70 Scopus citations


Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ERα and ERβ, and a number of putative membrane ERs, including ERα, ERβ, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and physiology has been discovered. In other cases, the identity or the function remains to be elucidated. This mini-review attempts to synthesize our understanding of 17β-estradiol membrane signaling within hypothalamic circuits involved in homeostatic functions, focusing on reproduction and energy balance.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
Issue number2
StatePublished - Sep 1 2012


  • 17β-estradiol
  • Estrogen receptor alpha
  • Estrogen receptor beta
  • GPR30 (GPER1)
  • Gonadotropin-releasing hormone neuron
  • Gαq-coupled membrane estrogen receptor
  • Proopiomelanocortin neuron
  • mGluR1 receptor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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