Membrane estrogen receptor regulation of hypothalamic function

Paul E. Micevych, Martin Kelly

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ERα and ERβ, and a number of putative membrane ERs, including ERα, ERβ, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and physiology has been discovered. In other cases, the identity or the function remains to be elucidated. This mini-review attempts to synthesize our understanding of 17β-estradiol membrane signaling within hypothalamic circuits involved in homeostatic functions, focusing on reproduction and energy balance.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
JournalNeuroendocrinology
Volume96
Issue number2
DOIs
StatePublished - Sep 2012

Fingerprint

Estrogen Receptors
Membranes
Estrogens
Reproduction
Estradiol
Pharmacology

Keywords

  • 17β-estradiol
  • Estrogen receptor alpha
  • Estrogen receptor beta
  • Gαq-coupled membrane estrogen receptor
  • Gonadotropin-releasing hormone neuron
  • GPR30 (GPER1)
  • mGluR1 receptor
  • Proopiomelanocortin neuron

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Membrane estrogen receptor regulation of hypothalamic function. / Micevych, Paul E.; Kelly, Martin.

In: Neuroendocrinology, Vol. 96, No. 2, 09.2012, p. 103-110.

Research output: Contribution to journalArticle

Micevych, Paul E. ; Kelly, Martin. / Membrane estrogen receptor regulation of hypothalamic function. In: Neuroendocrinology. 2012 ; Vol. 96, No. 2. pp. 103-110.
@article{521edb242f0b4a499cf5cd9a42580d22,
title = "Membrane estrogen receptor regulation of hypothalamic function",
abstract = "Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ERα and ERβ, and a number of putative membrane ERs, including ERα, ERβ, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and physiology has been discovered. In other cases, the identity or the function remains to be elucidated. This mini-review attempts to synthesize our understanding of 17β-estradiol membrane signaling within hypothalamic circuits involved in homeostatic functions, focusing on reproduction and energy balance.",
keywords = "17β-estradiol, Estrogen receptor alpha, Estrogen receptor beta, Gαq-coupled membrane estrogen receptor, Gonadotropin-releasing hormone neuron, GPR30 (GPER1), mGluR1 receptor, Proopiomelanocortin neuron",
author = "Micevych, {Paul E.} and Martin Kelly",
year = "2012",
month = "9",
doi = "10.1159/000338400",
language = "English (US)",
volume = "96",
pages = "103--110",
journal = "Neuroendocrinology",
issn = "0028-3835",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Membrane estrogen receptor regulation of hypothalamic function

AU - Micevych, Paul E.

AU - Kelly, Martin

PY - 2012/9

Y1 - 2012/9

N2 - Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ERα and ERβ, and a number of putative membrane ERs, including ERα, ERβ, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and physiology has been discovered. In other cases, the identity or the function remains to be elucidated. This mini-review attempts to synthesize our understanding of 17β-estradiol membrane signaling within hypothalamic circuits involved in homeostatic functions, focusing on reproduction and energy balance.

AB - Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ERα and ERβ, and a number of putative membrane ERs, including ERα, ERβ, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and physiology has been discovered. In other cases, the identity or the function remains to be elucidated. This mini-review attempts to synthesize our understanding of 17β-estradiol membrane signaling within hypothalamic circuits involved in homeostatic functions, focusing on reproduction and energy balance.

KW - 17β-estradiol

KW - Estrogen receptor alpha

KW - Estrogen receptor beta

KW - Gαq-coupled membrane estrogen receptor

KW - Gonadotropin-releasing hormone neuron

KW - GPR30 (GPER1)

KW - mGluR1 receptor

KW - Proopiomelanocortin neuron

UR - http://www.scopus.com/inward/record.url?scp=84866552268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866552268&partnerID=8YFLogxK

U2 - 10.1159/000338400

DO - 10.1159/000338400

M3 - Article

C2 - 22538318

AN - SCOPUS:84866552268

VL - 96

SP - 103

EP - 110

JO - Neuroendocrinology

JF - Neuroendocrinology

SN - 0028-3835

IS - 2

ER -