Abstract
Neuronal circadian oscillators in the mammalian and Drosophila brain express a circadian clock comprised of interlocking gene transcription feedback loops. The genetic clock regulates the membrane electrical activity by poorly understood signaling pathways to generate a circadian pattern of action potential firing. During the day, Na+channels contribute an excitatory drive for the spontaneous activity of circadian clock neurons. Multiple types of K+channels regulate the action potential firing pattern and the nightly reduction in neuronal activity. The membrane electrical activity possibly signaling by changes in intracellular Ca2+and cyclic adenosine monophosphate (cAMP) regulates the activity of the gene clock. A decline in the signaling pathways that link the gene clock and neural activity during aging and disease may weaken the circadian output and generate significant impacts on human health.
| Original language | English (US) |
|---|---|
| Article number | a027714 |
| Journal | Cold Spring Harbor perspectives in biology |
| Volume | 9 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2017 |
Fingerprint
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Membrane currents, gene expression, and circadian clocks. / Allen, Charles; Nitabach, Michael N.; Colwell, Christopher S.
In: Cold Spring Harbor perspectives in biology, Vol. 9, No. 5, a027714, 01.05.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Membrane currents, gene expression, and circadian clocks
AU - Allen, Charles
AU - Nitabach, Michael N.
AU - Colwell, Christopher S.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Neuronal circadian oscillators in the mammalian and Drosophila brain express a circadian clock comprised of interlocking gene transcription feedback loops. The genetic clock regulates the membrane electrical activity by poorly understood signaling pathways to generate a circadian pattern of action potential firing. During the day, Na+channels contribute an excitatory drive for the spontaneous activity of circadian clock neurons. Multiple types of K+channels regulate the action potential firing pattern and the nightly reduction in neuronal activity. The membrane electrical activity possibly signaling by changes in intracellular Ca2+and cyclic adenosine monophosphate (cAMP) regulates the activity of the gene clock. A decline in the signaling pathways that link the gene clock and neural activity during aging and disease may weaken the circadian output and generate significant impacts on human health.
AB - Neuronal circadian oscillators in the mammalian and Drosophila brain express a circadian clock comprised of interlocking gene transcription feedback loops. The genetic clock regulates the membrane electrical activity by poorly understood signaling pathways to generate a circadian pattern of action potential firing. During the day, Na+channels contribute an excitatory drive for the spontaneous activity of circadian clock neurons. Multiple types of K+channels regulate the action potential firing pattern and the nightly reduction in neuronal activity. The membrane electrical activity possibly signaling by changes in intracellular Ca2+and cyclic adenosine monophosphate (cAMP) regulates the activity of the gene clock. A decline in the signaling pathways that link the gene clock and neural activity during aging and disease may weaken the circadian output and generate significant impacts on human health.
UR - http://www.scopus.com/inward/record.url?scp=85009142258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009142258&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a027714
DO - 10.1101/cshperspect.a027714
M3 - Article
C2 - 28246182
AN - SCOPUS:85009142258
VL - 9
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
SN - 1943-0264
IS - 5
M1 - a027714
ER -