TY - JOUR
T1 - Membrane currents, gene expression, and circadian clocks
AU - Allen, Charles N.
AU - Nitabach, Michael N.
AU - Colwell, Christopher S.
N1 - Funding Information:
The work is supported by National Institutes of Health (NIH) Grants R01 NS036607 to C.N.A. and National Institute of Neurological Disorders and Stroke (NINDS) R01NS091070 and National Institute of General Medical Sciences (NIGMS) R01GM098931 to M.N.N.
Publisher Copyright:
© 2017 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2017/5
Y1 - 2017/5
N2 - Neuronal circadian oscillators in the mammalian and Drosophila brain express a circadian clock comprised of interlocking gene transcription feedback loops. The genetic clock regulates the membrane electrical activity by poorly understood signaling pathways to generate a circadian pattern of action potential firing. During the day, Na+channels contribute an excitatory drive for the spontaneous activity of circadian clock neurons. Multiple types of K+channels regulate the action potential firing pattern and the nightly reduction in neuronal activity. The membrane electrical activity possibly signaling by changes in intracellular Ca2+and cyclic adenosine monophosphate (cAMP) regulates the activity of the gene clock. A decline in the signaling pathways that link the gene clock and neural activity during aging and disease may weaken the circadian output and generate significant impacts on human health.
AB - Neuronal circadian oscillators in the mammalian and Drosophila brain express a circadian clock comprised of interlocking gene transcription feedback loops. The genetic clock regulates the membrane electrical activity by poorly understood signaling pathways to generate a circadian pattern of action potential firing. During the day, Na+channels contribute an excitatory drive for the spontaneous activity of circadian clock neurons. Multiple types of K+channels regulate the action potential firing pattern and the nightly reduction in neuronal activity. The membrane electrical activity possibly signaling by changes in intracellular Ca2+and cyclic adenosine monophosphate (cAMP) regulates the activity of the gene clock. A decline in the signaling pathways that link the gene clock and neural activity during aging and disease may weaken the circadian output and generate significant impacts on human health.
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U2 - 10.1101/cshperspect.a027714
DO - 10.1101/cshperspect.a027714
M3 - Article
C2 - 28246182
AN - SCOPUS:85009142258
SN - 1943-0264
VL - 9
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
IS - 5
M1 - a027714
ER -