Abstract
Neuronal circadian oscillators in the mammalian and Drosophila brain express a circadian clock comprised of interlocking gene transcription feedback loops. The genetic clock regulates the membrane electrical activity by poorly understood signaling pathways to generate a circadian pattern of action potential firing. During the day, Na+channels contribute an excitatory drive for the spontaneous activity of circadian clock neurons. Multiple types of K+channels regulate the action potential firing pattern and the nightly reduction in neuronal activity. The membrane electrical activity possibly signaling by changes in intracellular Ca2+and cyclic adenosine monophosphate (cAMP) regulates the activity of the gene clock. A decline in the signaling pathways that link the gene clock and neural activity during aging and disease may weaken the circadian output and generate significant impacts on human health.
Original language | English (US) |
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Article number | a027714 |
Journal | Cold Spring Harbor perspectives in biology |
Volume | 9 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2017 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Membrane currents, gene expression, and circadian clocks. / Allen, Charles; Nitabach, Michael N.; Colwell, Christopher S.
In: Cold Spring Harbor perspectives in biology, Vol. 9, No. 5, a027714, 01.05.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Membrane currents, gene expression, and circadian clocks
AU - Allen, Charles
AU - Nitabach, Michael N.
AU - Colwell, Christopher S.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Neuronal circadian oscillators in the mammalian and Drosophila brain express a circadian clock comprised of interlocking gene transcription feedback loops. The genetic clock regulates the membrane electrical activity by poorly understood signaling pathways to generate a circadian pattern of action potential firing. During the day, Na+channels contribute an excitatory drive for the spontaneous activity of circadian clock neurons. Multiple types of K+channels regulate the action potential firing pattern and the nightly reduction in neuronal activity. The membrane electrical activity possibly signaling by changes in intracellular Ca2+and cyclic adenosine monophosphate (cAMP) regulates the activity of the gene clock. A decline in the signaling pathways that link the gene clock and neural activity during aging and disease may weaken the circadian output and generate significant impacts on human health.
AB - Neuronal circadian oscillators in the mammalian and Drosophila brain express a circadian clock comprised of interlocking gene transcription feedback loops. The genetic clock regulates the membrane electrical activity by poorly understood signaling pathways to generate a circadian pattern of action potential firing. During the day, Na+channels contribute an excitatory drive for the spontaneous activity of circadian clock neurons. Multiple types of K+channels regulate the action potential firing pattern and the nightly reduction in neuronal activity. The membrane electrical activity possibly signaling by changes in intracellular Ca2+and cyclic adenosine monophosphate (cAMP) regulates the activity of the gene clock. A decline in the signaling pathways that link the gene clock and neural activity during aging and disease may weaken the circadian output and generate significant impacts on human health.
UR - http://www.scopus.com/inward/record.url?scp=85009142258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009142258&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a027714
DO - 10.1101/cshperspect.a027714
M3 - Article
C2 - 28246182
AN - SCOPUS:85009142258
VL - 9
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
SN - 1943-0264
IS - 5
M1 - a027714
ER -