Melatonin treatment of winter depression: A pilot study

Alfred J. Lewy; Vance K. Bauer; Neil L. Cutler; Robert L. Sack

doi:10.1016/S0165-1781(97)00128-5

Melatonin treatment of winter depression: A pilot study

Alfred J. Lewy, Vance K. Bauer, Neil L. Cutler, Robert L. Sack

Pediatrics

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Five patients with winter depression received low doses of melatonin in the afternoon, and five patients received placebo capsules. Melatonin treatment significantly decreased depression ratings compared to placebo. If these findings are replicated in a larger sample with documentation of expected phase shifts, the phase shift hypothesis will be substantially supported.

Original language	English (US)
Pages (from-to)	57-61
Number of pages	5
Journal	Psychiatry Research
Volume	77
Issue number	1
DOIs	https://doi.org/10.1016/S0165-1781(97)00128-5
State	Published - Jan 16 1998

Keywords

Melatonin
Melatonin phase response curve
Phase shift hypothesis
Seasonal affective disorder
Winter depression

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/S0165-1781(97)00128-5

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title = "Melatonin treatment of winter depression: A pilot study",

abstract = "Five patients with winter depression received low doses of melatonin in the afternoon, and five patients received placebo capsules. Melatonin treatment significantly decreased depression ratings compared to placebo. If these findings are replicated in a larger sample with documentation of expected phase shifts, the phase shift hypothesis will be substantially supported.",

keywords = "Melatonin, Melatonin phase response curve, Phase shift hypothesis, Seasonal affective disorder, Winter depression",

author = "Lewy, {Alfred J.} and Bauer, {Vance K.} and Cutler, {Neil L.} and Sack, {Robert L.}",

note = "Funding Information: Supported by Public Health grants ROl MH40161, KO2 MH01005 (RLS) and NARSAD vestigatorA ward to AJL).",

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AU - Cutler, Neil L.

AU - Sack, Robert L.

N1 - Funding Information: Supported by Public Health grants ROl MH40161, KO2 MH01005 (RLS) and NARSAD vestigatorA ward to AJL).

PY - 1998/1/16

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KW - Melatonin phase response curve

KW - Phase shift hypothesis

KW - Seasonal affective disorder

KW - Winter depression

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Melatonin treatment of winter depression: A pilot study

Abstract

Keywords

ASJC Scopus subject areas

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