Melatonin receptors activate heteromeric G-protein coupled Kir3 channels

Cole S. Nelson, Jennifer L. Marino, Charles Allen

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The effects of melatonin on circadian pacemaker activity in the central nervous system may be the result of melatonin receptor activation of G-protein coupled potassium channels which inhibit the action potential firing of neurons. Xenopus laevis and human(1a) melatonin receptors stimulated heteromeric G-protein activated inwardly rectifying potassium channels (Kir3.1/Kir3.2) when expressed in vitro in oocytes. Pertussis toxin reduced iodo-melatonin (87.1% reduction) and melatonin (90.3% reduction) stimulated currents in a time-dependent manner for cells expressing X. laevis receptors. A similar pertussis toxin inhibition was observed for human melatonin receptors (melatonin, 78.9% reduction). This suggests a potential role for heteromeric Kir3 channels in the receptor-mediated actions of melatonin in vivo.

Original languageEnglish (US)
Pages (from-to)717-720
Number of pages4
JournalNeuroReport
Volume7
Issue number3
StatePublished - 1996

Fingerprint

Melatonin Receptors
Melatonin
GTP-Binding Proteins
Pertussis Toxin
Xenopus laevis
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Inwardly Rectifying Potassium Channel
Potassium Channels
Action Potentials
Oocytes
Central Nervous System
Neurons

Keywords

  • Kir3
  • Melatonin
  • Melatonin receptor
  • Oocyte
  • Pertussis toxin
  • Potassium channel

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Melatonin receptors activate heteromeric G-protein coupled Kir3 channels. / Nelson, Cole S.; Marino, Jennifer L.; Allen, Charles.

In: NeuroReport, Vol. 7, No. 3, 1996, p. 717-720.

Research output: Contribution to journalArticle

Nelson, Cole S. ; Marino, Jennifer L. ; Allen, Charles. / Melatonin receptors activate heteromeric G-protein coupled Kir3 channels. In: NeuroReport. 1996 ; Vol. 7, No. 3. pp. 717-720.
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