Melanopsin is required for non-image-forming photic responses in blind mice

Satchidananda Panda, Ignacio Provencio, Daniel Tu, Susana S. Pires, Mark D. Rollag, Ana Maria Castrucci, Mathew T. Pletcher, Trey K. Sato, Tim Wiltshire, Mary Andahazy, Steve A. Kay, Russell N. Van Gelder, John B. Hogenesch

Research output: Contribution to journalArticle

488 Citations (Scopus)

Abstract

Although mice lacking rod and cone photoreceptors are blind, they retain many eye-mediated responses to light, possibly through photosensitive retinal ganglion cells. These cells express melanopsin, a photopigment that confers this photosensitivity. Mice lacking melanopsin still retain nonvisual photoreception, suggesting that rods and cones could operate in this capacity. We observed that mice with both outer-retinal degeneration and a deficiency in melanopsin exhibited complete loss of photoentrainment of the circadian oscillator, pupillary light responses, photic suppression of arylalkylamine-N-acetyltransferase transcript, and acute suppression of locomotor activity by light. This indicates the importance of both nonvisual and classical visual photoreceptor systems for nonvisual photic responses in mammals.

Original languageEnglish (US)
Pages (from-to)525-527
Number of pages3
JournalScience
Volume301
Issue number5632
DOIs
StatePublished - Jul 25 2003
Externally publishedYes

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Vertebrate Photoreceptor Cells
Light
Arylalkylamine N-Acetyltransferase
Retinal Cone Photoreceptor Cells
Retinal Rod Photoreceptor Cells
Retinal Degeneration
Retinal Ganglion Cells
Locomotion
Mammals
melanopsin

ASJC Scopus subject areas

  • General

Cite this

Panda, S., Provencio, I., Tu, D., Pires, S. S., Rollag, M. D., Castrucci, A. M., ... Hogenesch, J. B. (2003). Melanopsin is required for non-image-forming photic responses in blind mice. Science, 301(5632), 525-527. https://doi.org/10.1126/science.1086179

Melanopsin is required for non-image-forming photic responses in blind mice. / Panda, Satchidananda; Provencio, Ignacio; Tu, Daniel; Pires, Susana S.; Rollag, Mark D.; Castrucci, Ana Maria; Pletcher, Mathew T.; Sato, Trey K.; Wiltshire, Tim; Andahazy, Mary; Kay, Steve A.; Van Gelder, Russell N.; Hogenesch, John B.

In: Science, Vol. 301, No. 5632, 25.07.2003, p. 525-527.

Research output: Contribution to journalArticle

Panda, S, Provencio, I, Tu, D, Pires, SS, Rollag, MD, Castrucci, AM, Pletcher, MT, Sato, TK, Wiltshire, T, Andahazy, M, Kay, SA, Van Gelder, RN & Hogenesch, JB 2003, 'Melanopsin is required for non-image-forming photic responses in blind mice', Science, vol. 301, no. 5632, pp. 525-527. https://doi.org/10.1126/science.1086179
Panda S, Provencio I, Tu D, Pires SS, Rollag MD, Castrucci AM et al. Melanopsin is required for non-image-forming photic responses in blind mice. Science. 2003 Jul 25;301(5632):525-527. https://doi.org/10.1126/science.1086179
Panda, Satchidananda ; Provencio, Ignacio ; Tu, Daniel ; Pires, Susana S. ; Rollag, Mark D. ; Castrucci, Ana Maria ; Pletcher, Mathew T. ; Sato, Trey K. ; Wiltshire, Tim ; Andahazy, Mary ; Kay, Steve A. ; Van Gelder, Russell N. ; Hogenesch, John B. / Melanopsin is required for non-image-forming photic responses in blind mice. In: Science. 2003 ; Vol. 301, No. 5632. pp. 525-527.
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