Melanonychia

Julie Jefferson, Phoebe Rich

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Melanonychia, or melanin-derived brown-to-black nail pigmentation, is a diagnostic challenge for clinicians. The most serious disease of the nail unit, melanoma, primarily presents with melanonychia. However, melanonychia most often occurs as a result of benign etiologies such as nail matrix melanocytic activation, nail matrix melanocytic hyperplasia, and nail invasion by melanin-producing pathogens. Regrettably, patients with nail apparatus melanoma are often initially misdiagnosed, and due to diagnostic delays of an average of 2 years, melanoma of the nail unit carries a poor prognosis. Having a thorough knowledge of the various causes of melanonychia and using a systematic approach when evaluating brown-to-black nail pigmentation may help prevent misdiagnosis and thereby improve prognosis.

Original languageEnglish (US)
Article number952186
JournalDermatology Research and Practice
Volume2012
DOIs
StatePublished - Dec 1 2012

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Nails
Melanoma
Melanins
Pigmentation
Diagnostic Errors
Nail Diseases
Hyperplasia

ASJC Scopus subject areas

  • Dermatology

Cite this

Melanonychia. / Jefferson, Julie; Rich, Phoebe.

In: Dermatology Research and Practice, Vol. 2012, 952186, 01.12.2012.

Research output: Contribution to journalReview article

Jefferson, Julie ; Rich, Phoebe. / Melanonychia. In: Dermatology Research and Practice. 2012 ; Vol. 2012.
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