@article{9311a879f6d543618228676172efaa37,
title = "Melanoma risk assessment based on relatives{\textquoteright} age at diagnosis",
abstract = "Purpose: The aim of this study was to determine risk for melanoma among individuals who have a first- or second-degree relative with a history of melanoma, based on the unaffected individual{\textquoteright}s age and age at diagnosis of the relative. Methods: The study employed a case–control design using a statewide database linked with a Surveillance Epidemiology and End Results cancer registry. A population-based sample of individuals who received at least one diagnosis of first primary, malignant melanoma (n = 14,281), as well as their first- and second-degree relatives, was included. Control individuals with no history of melanoma (n = 70,889) were matched to cases on birth year, gender, race/ethnicity, and county at birth. Results: Risk for melanoma among relatives of melanoma patients declined with relative{\textquoteright}s age and age at diagnosis. Individuals between ages 40 and 49 who are first-degree relatives of melanoma patients diagnosed between ages 40 and 49 had the greatest risk for melanoma compared with individuals without a first-degree relative with a melanoma history (HR 4.89; 95% CI 3.11–7.68). Increased melanoma risk among second-degree relatives of patients was typically lower than that for first-degree relatives. Conclusions: Risk for melanoma, at earlier ages than expected, is increased among relatives of individuals with a history of melanoma, particularly if the melanoma case was diagnosed at a young age. Further research on the relationship between age at diagnosis and relative{\textquoteright}s melanoma risk could inform melanoma screening recommendations for individuals with a family history of the disease.",
keywords = "Age at diagnosis, Early detection, Familial risk, Melanoma",
author = "Wu, {Yelena P.} and Wendy Kohlmann and Karen Curtin and Zhe Yu and Hanson, {Heidi A.} and Mia Hashibe and Parsons, {Bridget G.} and Jathine Wong and Schiffman, {Joshua D.} and Douglas Grossman and Leachman, {Sancy A.}",
note = "Funding Information: Acknowledgments We appreciate the assistance of Ayesha Patil and Linda Barton in manuscript preparation. This work was supported by an Academic Career Award from the National Cancer Institute (NCI) at the National Institutes of Health (K07CA196985) and the Huntsman Cancer Institute to Y.P.W.; and the Building Interdisciplinary Research in Women{\textquoteright}s Health career award (1K12HD085852) to H.A.H.; NCI R01 CA158322 to S.A.L.; National Institutes of Health (P30CA042014) to the Huntsman Cancer Institute, Genetic Counseling and Pedigree and Population (Utah Population Database) shared resources; the Huntsman Cancer Foundation, for its support of the Pedigree and Population resource for the ongoing collection, maintenance, and support of the Utah Population Database; the Utah Cancer Registry, funded by contract HHSN261201000026C from NCI{\textquoteright}s SEER Program with additional support from the Utah State Department of Health and the University of Utah. Dr. Grossman was supported in part by the Department of Dermatology at the University of Utah. Effort by Dr. Leachman was supported in part by the Oregon Health and Science University Knight Cancer Institute. Dr. Schiffman was supported by the Edward B. Clark, MD Chair in Pediatric Research and the Primary Children{\textquoteright}s Hospital (PCH) Pediatric Cancer Research Program, funded by the Intermountain Healthcare Foundation and PCH Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: We appreciate the assistance of Ayesha Patil and Linda Barton in manuscript preparation. This work was supported by an Academic Career Award from the National Cancer Institute (NCI) at the National Institutes of Health (K07CA196985) and the Huntsman Cancer Institute to Y.P.W.; and the Building Interdisciplinary Research in Women?s Health career award (1K12HD085852) to H.A.H.; NCI R01 CA158322 to S.A.L.; National Institutes of Health (P30CA042014) to the Huntsman Cancer Institute, Genetic Counseling and Pedigree and Population (Utah Population Database) shared resources; the Huntsman Cancer Foundation, for its support of the Pedigree and Population resource for the ongoing collection, maintenance, and support of the Utah Population Database; the Utah Cancer Registry, funded by contract HHSN261201000026C from NCI?s SEER Program with additional support from the Utah State Department of Health and the University of Utah. Dr. Grossman was supported in part by the Department of Dermatology at the University of Utah. Effort by Dr. Leachman was supported in part by the Oregon Health and Science University Knight Cancer Institute. Dr. Schiffman was supported by the Edward B. Clark, MD Chair in Pediatric Research and the Primary Children?s Hospital (PCH) Pediatric Cancer Research Program, funded by the Intermountain Healthcare Foundation and PCH Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2017, Springer International Publishing AG, part of Springer Nature.",
year = "2018",
month = feb,
day = "1",
doi = "10.1007/s10552-017-0994-8",
language = "English (US)",
volume = "29",
pages = "193--199",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "2",
}