Melanoma mimic: A case of multiple pagetoid Spitz nevi

KaLynne Harris, Scott R. Florell, Jason Papenfuss, Wendy Kohlmann, Mona Jahromi, Joshua D. Schiffman, John Quackenbush, Pamela Cassidy, Sancy Leachman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Differentiating Spitz nevi from melanoma can be difficult. Pagetoid spread of melanocytes is among the features making diagnosis difficult. Rare reports of isolated pagetoid Spitz nevi exist. Observations: We present a unique case of multiple pagetoid Spitz nevi initially diagnosed as multiple in situ melanomas. Germline karyotyping, CDK4 and CDKN2A sequencing, and comparative genomic hybridization ofHRAS, BRAF, KRAS, RAF1, CDKN2A, Rb1, MAP2K1, MAP2K2, PTEN, and PTPN11 genes did not identify mutations in this case. Germline and somatic sequencing of BRAF exon 15 revealed no mutations at V600D/E/K. In addition, singlenucleotide polymorphism microarray analysis (330K) on lesional and normal skin revealed no genome-wide copy number changes or loss of heterozygosity. Conclusions: Clinicians should be aware of the occurrence of multiple pagetoid Spitz nevi to avoid morbidity associated with the misdiagnosis of multiple melanomas. The genetic mechanisms of pagetoid spread of melanocytes are not fully understood.

Original languageEnglish (US)
Pages (from-to)370-374
Number of pages5
JournalArchives of Dermatology
Volume148
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Fingerprint

Epithelioid and Spindle Cell Nevus
Melanoma
Melanocytes
Nevi and Melanomas
Karyotyping
Mutation
Comparative Genomic Hybridization
Loss of Heterozygosity
Microarray Analysis
Diagnostic Errors
Exons
Genome
Morbidity
Skin
Genes

ASJC Scopus subject areas

  • Dermatology

Cite this

Harris, K., Florell, S. R., Papenfuss, J., Kohlmann, W., Jahromi, M., Schiffman, J. D., ... Leachman, S. (2012). Melanoma mimic: A case of multiple pagetoid Spitz nevi. Archives of Dermatology, 148(3), 370-374. https://doi.org/10.1001/archdermatol.2011.356

Melanoma mimic : A case of multiple pagetoid Spitz nevi. / Harris, KaLynne; Florell, Scott R.; Papenfuss, Jason; Kohlmann, Wendy; Jahromi, Mona; Schiffman, Joshua D.; Quackenbush, John; Cassidy, Pamela; Leachman, Sancy.

In: Archives of Dermatology, Vol. 148, No. 3, 03.2012, p. 370-374.

Research output: Contribution to journalArticle

Harris, K, Florell, SR, Papenfuss, J, Kohlmann, W, Jahromi, M, Schiffman, JD, Quackenbush, J, Cassidy, P & Leachman, S 2012, 'Melanoma mimic: A case of multiple pagetoid Spitz nevi', Archives of Dermatology, vol. 148, no. 3, pp. 370-374. https://doi.org/10.1001/archdermatol.2011.356
Harris K, Florell SR, Papenfuss J, Kohlmann W, Jahromi M, Schiffman JD et al. Melanoma mimic: A case of multiple pagetoid Spitz nevi. Archives of Dermatology. 2012 Mar;148(3):370-374. https://doi.org/10.1001/archdermatol.2011.356
Harris, KaLynne ; Florell, Scott R. ; Papenfuss, Jason ; Kohlmann, Wendy ; Jahromi, Mona ; Schiffman, Joshua D. ; Quackenbush, John ; Cassidy, Pamela ; Leachman, Sancy. / Melanoma mimic : A case of multiple pagetoid Spitz nevi. In: Archives of Dermatology. 2012 ; Vol. 148, No. 3. pp. 370-374.
@article{fd1b5dfc569b440f8bc6650f191b7717,
title = "Melanoma mimic: A case of multiple pagetoid Spitz nevi",
abstract = "Background: Differentiating Spitz nevi from melanoma can be difficult. Pagetoid spread of melanocytes is among the features making diagnosis difficult. Rare reports of isolated pagetoid Spitz nevi exist. Observations: We present a unique case of multiple pagetoid Spitz nevi initially diagnosed as multiple in situ melanomas. Germline karyotyping, CDK4 and CDKN2A sequencing, and comparative genomic hybridization ofHRAS, BRAF, KRAS, RAF1, CDKN2A, Rb1, MAP2K1, MAP2K2, PTEN, and PTPN11 genes did not identify mutations in this case. Germline and somatic sequencing of BRAF exon 15 revealed no mutations at V600D/E/K. In addition, singlenucleotide polymorphism microarray analysis (330K) on lesional and normal skin revealed no genome-wide copy number changes or loss of heterozygosity. Conclusions: Clinicians should be aware of the occurrence of multiple pagetoid Spitz nevi to avoid morbidity associated with the misdiagnosis of multiple melanomas. The genetic mechanisms of pagetoid spread of melanocytes are not fully understood.",
author = "KaLynne Harris and Florell, {Scott R.} and Jason Papenfuss and Wendy Kohlmann and Mona Jahromi and Schiffman, {Joshua D.} and John Quackenbush and Pamela Cassidy and Sancy Leachman",
year = "2012",
month = "3",
doi = "10.1001/archdermatol.2011.356",
language = "English (US)",
volume = "148",
pages = "370--374",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "3",

}

TY - JOUR

T1 - Melanoma mimic

T2 - A case of multiple pagetoid Spitz nevi

AU - Harris, KaLynne

AU - Florell, Scott R.

AU - Papenfuss, Jason

AU - Kohlmann, Wendy

AU - Jahromi, Mona

AU - Schiffman, Joshua D.

AU - Quackenbush, John

AU - Cassidy, Pamela

AU - Leachman, Sancy

PY - 2012/3

Y1 - 2012/3

N2 - Background: Differentiating Spitz nevi from melanoma can be difficult. Pagetoid spread of melanocytes is among the features making diagnosis difficult. Rare reports of isolated pagetoid Spitz nevi exist. Observations: We present a unique case of multiple pagetoid Spitz nevi initially diagnosed as multiple in situ melanomas. Germline karyotyping, CDK4 and CDKN2A sequencing, and comparative genomic hybridization ofHRAS, BRAF, KRAS, RAF1, CDKN2A, Rb1, MAP2K1, MAP2K2, PTEN, and PTPN11 genes did not identify mutations in this case. Germline and somatic sequencing of BRAF exon 15 revealed no mutations at V600D/E/K. In addition, singlenucleotide polymorphism microarray analysis (330K) on lesional and normal skin revealed no genome-wide copy number changes or loss of heterozygosity. Conclusions: Clinicians should be aware of the occurrence of multiple pagetoid Spitz nevi to avoid morbidity associated with the misdiagnosis of multiple melanomas. The genetic mechanisms of pagetoid spread of melanocytes are not fully understood.

AB - Background: Differentiating Spitz nevi from melanoma can be difficult. Pagetoid spread of melanocytes is among the features making diagnosis difficult. Rare reports of isolated pagetoid Spitz nevi exist. Observations: We present a unique case of multiple pagetoid Spitz nevi initially diagnosed as multiple in situ melanomas. Germline karyotyping, CDK4 and CDKN2A sequencing, and comparative genomic hybridization ofHRAS, BRAF, KRAS, RAF1, CDKN2A, Rb1, MAP2K1, MAP2K2, PTEN, and PTPN11 genes did not identify mutations in this case. Germline and somatic sequencing of BRAF exon 15 revealed no mutations at V600D/E/K. In addition, singlenucleotide polymorphism microarray analysis (330K) on lesional and normal skin revealed no genome-wide copy number changes or loss of heterozygosity. Conclusions: Clinicians should be aware of the occurrence of multiple pagetoid Spitz nevi to avoid morbidity associated with the misdiagnosis of multiple melanomas. The genetic mechanisms of pagetoid spread of melanocytes are not fully understood.

UR - http://www.scopus.com/inward/record.url?scp=84858716821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858716821&partnerID=8YFLogxK

U2 - 10.1001/archdermatol.2011.356

DO - 10.1001/archdermatol.2011.356

M3 - Article

C2 - 22105811

AN - SCOPUS:84858716821

VL - 148

SP - 370

EP - 374

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 3

ER -