Melanoma genetic counseling and test reporting improve screening adherence among unaffected carriers 2 years later

Lisa G. Aspinwall, Jennifer M. Taber, Samantha L. Leaf, Wendy Kohlmann, Sancy Leachman

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background:Amajor goal of predictive genetic testing for melanoma is to promote early detection to reduce mortality. This study evaluated the long-term impact of melanoma genetic test reporting and counseling on screening adherence. Methods: This study assessed adherence to recommendations for annual total body skin examinations (TBSE) and monthly skin self-examinations (SSE) among 37 members of Utah CDKN2A/p16 kindreds (10 unaffected carriers, 11 affected carriers, and 16 unaffected noncarriers; response rate = 64.9% of eligible participants). Results: Two years following test reporting, adherence to annual TBSE among unaffected carriers increased from 40% to 70%. However, unaffected noncarriers' adherence decreased from 56% to 13%. Affected carriers reported TBSEs at both assessments (91% and 82%, respectively). Monthly SSE frequency remained highly variable in all patient groups: at 2 years, 29.7% reported monthly SSEs, 27.0% reported more frequent selfexaminations, and 43.2% reported underscreening. However, SSE quality improved significantly: participants checked more body sites at 2 years than at baseline, especially feet, shoulders, legs, and genitals. Perceived logistic barriers to TBSEs (e.g., expensive, inconvenient) and SSEs (hard to remember, time-consuming) predicted wer adherence. Conclusions: Unaffected carriers reported increased TBSE adherence and thoroughness of SSEs 2 years following melanoma genetic test reporting, suggesting clinical benefit in this modest sample. Unaffected noncarriers reported comparable gains in SSE thoroughness, but decreased TBSEs. Impact: Melanoma genetic counseling and test reporting may improve adherence among unaffected carrier members of p16 families. Further interventions to reduce logistic barriers and to promote continued screening adherence among unaffected noncarrier family members may be needed.

Original languageEnglish (US)
Pages (from-to)1687-1697
Number of pages11
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

Fingerprint

Genetic Counseling
Melanoma
Self-Examination
Skin
Genetic Testing
Foot
Counseling
Leg
Mortality

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Melanoma genetic counseling and test reporting improve screening adherence among unaffected carriers 2 years later. / Aspinwall, Lisa G.; Taber, Jennifer M.; Leaf, Samantha L.; Kohlmann, Wendy; Leachman, Sancy.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 22, No. 10, 10.2013, p. 1687-1697.

Research output: Contribution to journalArticle

Aspinwall, Lisa G. ; Taber, Jennifer M. ; Leaf, Samantha L. ; Kohlmann, Wendy ; Leachman, Sancy. / Melanoma genetic counseling and test reporting improve screening adherence among unaffected carriers 2 years later. In: Cancer Epidemiology Biomarkers and Prevention. 2013 ; Vol. 22, No. 10. pp. 1687-1697.
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abstract = "Background:Amajor goal of predictive genetic testing for melanoma is to promote early detection to reduce mortality. This study evaluated the long-term impact of melanoma genetic test reporting and counseling on screening adherence. Methods: This study assessed adherence to recommendations for annual total body skin examinations (TBSE) and monthly skin self-examinations (SSE) among 37 members of Utah CDKN2A/p16 kindreds (10 unaffected carriers, 11 affected carriers, and 16 unaffected noncarriers; response rate = 64.9{\%} of eligible participants). Results: Two years following test reporting, adherence to annual TBSE among unaffected carriers increased from 40{\%} to 70{\%}. However, unaffected noncarriers' adherence decreased from 56{\%} to 13{\%}. Affected carriers reported TBSEs at both assessments (91{\%} and 82{\%}, respectively). Monthly SSE frequency remained highly variable in all patient groups: at 2 years, 29.7{\%} reported monthly SSEs, 27.0{\%} reported more frequent selfexaminations, and 43.2{\%} reported underscreening. However, SSE quality improved significantly: participants checked more body sites at 2 years than at baseline, especially feet, shoulders, legs, and genitals. Perceived logistic barriers to TBSEs (e.g., expensive, inconvenient) and SSEs (hard to remember, time-consuming) predicted wer adherence. Conclusions: Unaffected carriers reported increased TBSE adherence and thoroughness of SSEs 2 years following melanoma genetic test reporting, suggesting clinical benefit in this modest sample. Unaffected noncarriers reported comparable gains in SSE thoroughness, but decreased TBSEs. Impact: Melanoma genetic counseling and test reporting may improve adherence among unaffected carrier members of p16 families. Further interventions to reduce logistic barriers and to promote continued screening adherence among unaffected noncarrier family members may be needed.",
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AB - Background:Amajor goal of predictive genetic testing for melanoma is to promote early detection to reduce mortality. This study evaluated the long-term impact of melanoma genetic test reporting and counseling on screening adherence. Methods: This study assessed adherence to recommendations for annual total body skin examinations (TBSE) and monthly skin self-examinations (SSE) among 37 members of Utah CDKN2A/p16 kindreds (10 unaffected carriers, 11 affected carriers, and 16 unaffected noncarriers; response rate = 64.9% of eligible participants). Results: Two years following test reporting, adherence to annual TBSE among unaffected carriers increased from 40% to 70%. However, unaffected noncarriers' adherence decreased from 56% to 13%. Affected carriers reported TBSEs at both assessments (91% and 82%, respectively). Monthly SSE frequency remained highly variable in all patient groups: at 2 years, 29.7% reported monthly SSEs, 27.0% reported more frequent selfexaminations, and 43.2% reported underscreening. However, SSE quality improved significantly: participants checked more body sites at 2 years than at baseline, especially feet, shoulders, legs, and genitals. Perceived logistic barriers to TBSEs (e.g., expensive, inconvenient) and SSEs (hard to remember, time-consuming) predicted wer adherence. Conclusions: Unaffected carriers reported increased TBSE adherence and thoroughness of SSEs 2 years following melanoma genetic test reporting, suggesting clinical benefit in this modest sample. Unaffected noncarriers reported comparable gains in SSE thoroughness, but decreased TBSEs. Impact: Melanoma genetic counseling and test reporting may improve adherence among unaffected carrier members of p16 families. Further interventions to reduce logistic barriers and to promote continued screening adherence among unaffected noncarrier family members may be needed.

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