Melanin concentrating hormone (MCH): A novel neural pathway for regulation of GnRH neurons

Patricia S. Williamson-Hughes, Kevin Grove, M (Susan) Smith

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Abstract

    The link between the state of energy balance and reproductive function is well known. Thus, signals denoting negative energy balance and the accompanying hyperphagic drive are likely to be factors in the suppression of gonadotropin releasing hormone (GnRH) activity. We have previously found that appetite-regulating systems, such as neuropeptide Y (NPY) in the arcuate nucleus (ARH) and orexin in the lateral hypothalamic area (LHA), send fiber projections that come in close apposition with GnRH neurons. Furthermore, the appropriate receptors, NPY Y5 and OR-1, respectively, are coexpressed on GnRH neurons, providing neuroanatomical evidence for a direct link between the NPY and orexin systems and GnRH neurons. Therefore, these orexigenic neuropeptide systems are potential candidates that convey information about energy balance to GnRH neurons. The current studies focused on melanin concentrating hormone (MCH), another orexigenic neuropeptide system located in the LHA that is sensitive to energy balance. The results showed that MCH fiber projections came in close apposition with approximately 85-90% of GnRH cell bodies throughout the preoptic area and anterior hypothalamic area in the rat. In addition, the MCH receptor (MCHR1) was coexpressed on about 50-55% of GnRH neurons. These findings present evidence for a possible direct neuroanatomical pathway by which MCH may play a role in the regulation of GnRH neuronal function. Thus, MCH is another potential signal that may serve to integrate energy balance and reproductive function.

    Original languageEnglish (US)
    Pages (from-to)117-124
    Number of pages8
    JournalBrain Research
    Volume1041
    Issue number2
    DOIs
    StatePublished - Apr 18 2005

    Fingerprint

    Neural Pathways
    Gonadotropin-Releasing Hormone
    Neurons
    Lateral Hypothalamic Area
    Neuropeptide Y
    Neuropeptides
    Anterior Hypothalamic Nucleus
    Neuropeptide Y Receptors
    Arcuate Nucleus of Hypothalamus
    Preoptic Area
    melanin-concentrating hormone
    Appetite

    Keywords

    • Confocal microscopy
    • GnRH
    • Immunofluorescence
    • MCH
    • MCHR1
    • Neuroanatomy

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Melanin concentrating hormone (MCH) : A novel neural pathway for regulation of GnRH neurons. / Williamson-Hughes, Patricia S.; Grove, Kevin; Smith, M (Susan).

    In: Brain Research, Vol. 1041, No. 2, 18.04.2005, p. 117-124.

    Research output: Contribution to journalArticle

    Williamson-Hughes, Patricia S. ; Grove, Kevin ; Smith, M (Susan). / Melanin concentrating hormone (MCH) : A novel neural pathway for regulation of GnRH neurons. In: Brain Research. 2005 ; Vol. 1041, No. 2. pp. 117-124.
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    abstract = "The link between the state of energy balance and reproductive function is well known. Thus, signals denoting negative energy balance and the accompanying hyperphagic drive are likely to be factors in the suppression of gonadotropin releasing hormone (GnRH) activity. We have previously found that appetite-regulating systems, such as neuropeptide Y (NPY) in the arcuate nucleus (ARH) and orexin in the lateral hypothalamic area (LHA), send fiber projections that come in close apposition with GnRH neurons. Furthermore, the appropriate receptors, NPY Y5 and OR-1, respectively, are coexpressed on GnRH neurons, providing neuroanatomical evidence for a direct link between the NPY and orexin systems and GnRH neurons. Therefore, these orexigenic neuropeptide systems are potential candidates that convey information about energy balance to GnRH neurons. The current studies focused on melanin concentrating hormone (MCH), another orexigenic neuropeptide system located in the LHA that is sensitive to energy balance. The results showed that MCH fiber projections came in close apposition with approximately 85-90{\%} of GnRH cell bodies throughout the preoptic area and anterior hypothalamic area in the rat. In addition, the MCH receptor (MCHR1) was coexpressed on about 50-55{\%} of GnRH neurons. These findings present evidence for a possible direct neuroanatomical pathway by which MCH may play a role in the regulation of GnRH neuronal function. Thus, MCH is another potential signal that may serve to integrate energy balance and reproductive function.",
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