Meibomian gland morphology and tear osmolarity: Changes with accutane therapy

William Mathers, W. J. Shields, M. S. Sachdev, W. M. Petroll, J. V. Jester

Research output: Contribution to journalArticle

95 Scopus citations


We evaluated the meibomian gland function of 11 patients before and during treatment with isotretinoin (Accutane) by assessing tear osmolarity, meibomian gland morphology, tear production, rose bengal staining, and meibomian gland excreta. We found, during Accutane use, that atrophic by meibography. Excreta thickness increased from 1.7 ± 0.9 to 3.1 ± 1.2 (p <0.005), and expressible excreta volume decreased from 1.52 ± 0.68 to 1.10 ± 0.3 (p <0.05) (scale 1-4). We also found a significant increase in tear osmolarity from 304.9 ± 11 to 316.3 ± 10 mosmol/L (p <0.005). There was no significant change in the Schirmer test during treatment. We suggest that the clinical symptoms of blepharitis during Accutane therapy are related to decreased meibomian gland function and consequent increased tear evaporation and tear osmolarity.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
Issue number4
Publication statusPublished - 1991
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology

Cite this

Mathers, W., Shields, W. J., Sachdev, M. S., Petroll, W. M., & Jester, J. V. (1991). Meibomian gland morphology and tear osmolarity: Changes with accutane therapy. Cornea, 10(4), 286-290.