@article{b3c595d2f7ee4d0fa36d34d7b355a5f9,
title = "Medulloblastomics: The end of the beginning",
abstract = "The division of medulloblastoma into different subgroups by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients are readily apparent, pinpointing previously unappreciated diagnostic and therapeutic targets. In this Review, we summarize the 'explosion' of data emerging from the application of modern genomics to medulloblastoma, and in particular the recurrent targets of mutation in medulloblastoma subgroups. These data are currently making their way into clinical trials as we seek to integrate conventional and molecularly targeted therapies.",
author = "Northcott, {Paul A.} and Jones, {David T.W.} and Marcel Kool and Robinson, {Giles W.} and Gilbertson, {Richard J.} and Cho, {Yoon Jae} and Pomeroy, {Scott L.} and Andrey Korshunov and Peter Lichter and Taylor, {Michael D.} and Pfister, {Stefan M.}",
note = "Funding Information: This work was principally supported by the PedBrain Tumour Project contributing to the International Cancer Genome Consortium (ICGC), funded by German Cancer Aid (109252) and the German Federal Ministry of Education and Research (BMBF, NGFNplus #01GS0883). The authors also acknowledge the Pediatric Brain Tumour Foundation (PBTFUS), the US National Institutes of Health (R01CA148699 and R01CA159859) and the Dutch Cancer Foundations KWF (2010-4713) and KIKA. P.A.N. is a Roman Herzog PostDoctoral Fellow supported by the Hertie Foundation and the DKFZ. The authors are deeply indebted to C. Smith of Creative Science Studios for assistance with artwork. They also acknowledge C. Imbusch (DKFZ) for bioinformatic support pertaining to the meta-analysis of next-generation sequencing studies. Last, special acknowledgments are warranted for T. J. Pugh (Broad Institute), N. J{\"a}ger (DKFZ) and D. J. H. Shih (SickKids) who played lead bioinformatic roles in the respective medulloblastoma genomic studies highlighted in this Review.",
year = "2012",
month = dec,
doi = "10.1038/nrc3410",
language = "English (US)",
volume = "12",
pages = "818--834",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "12",
}