Medullary thyroid carcinoma identified by cell-free translation of tumor messenger ribonucleic acid in a patient with a neck mass and the syndrome of ectopic adrenocorticotropin

William W. Chin, Richard H. Goodman, John W. Jacobs, Hubert J. Wolfe, Gilbert H. Daniels, Joel F. Habener

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We report a patient who presented with a lateral neck mass and Cushing's syndrome secondary to the ectopic production of ACTH. The initial diagnosis was a nonchromaffin paraganglioma based on conventional light and electron microscopic studies. However, during this patient's hospital course, we determined that mRNA extracted from the tumor directed the translation of a calcitonin precursor in a cell-free system. This finding led to a consideration of the diagnosis of medullary thyroid carcinoma, which was then confirmed by further endocrine and histological evaluations. This is a report ofthe identification of a tumor type using techniques of molecular biology.

Original languageEnglish (US)
Pages (from-to)572-575
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume52
Issue number3
DOIs
StatePublished - Mar 1981

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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