Medullary thyroid carcinoma identified by cell-free translation of tumor messenger ribonucleic acid in a patient with a neck mass and the syndrome of ectopic adrenocorticotropin

W. W. Chin, Richard Goodman, J. W. Jacobs, H. J. Wolfe, G. H. Daniels, J. F. Habener

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report a patient who presented with a lateral neck mass and Cushing's syndrome secondary to the ectopic production of ACTH. The initial diagnosis was a nonchromaffin paraganglioma based on conventional light and electron microscopic studies. However, during this patient's hospital course, we determined that mRNA extracted from the tumor directed the translation of a calcitonin precursor in a cell-free system. This finding led to a consideration of the diagnosis of medullary thyroid carcinoma, which was then confirmed by further endocrine and histological evaluations. This is a report of the identification of a tumor type using techniques of molecular biology.

Original languageEnglish (US)
Pages (from-to)572-575
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume52
Issue number3
StatePublished - 1981
Externally publishedYes

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Adrenocorticotropic Hormone
Tumors
Neck
Extra-Adrenal Paraganglioma
RNA
Molecular biology
Cell-Free System
Cushing Syndrome
Calcitonin
Molecular Biology
Neoplasms
Electrons
Light
Messenger RNA
Medullary Thyroid cancer

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Medullary thyroid carcinoma identified by cell-free translation of tumor messenger ribonucleic acid in a patient with a neck mass and the syndrome of ectopic adrenocorticotropin. / Chin, W. W.; Goodman, Richard; Jacobs, J. W.; Wolfe, H. J.; Daniels, G. H.; Habener, J. F.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 52, No. 3, 1981, p. 572-575.

Research output: Contribution to journalArticle

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AU - Wolfe, H. J.

AU - Daniels, G. H.

AU - Habener, J. F.

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