Medication adherence in healthy elders

Small cognitive changes make a big difference

Tamara L. Hayes, Nicole Larimer, Andre Adami, Jeffrey Kaye

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Objective: This was a cross-sectional study of the ability of independently living healthy elders to follow a medication regimen. Participants were divided into a group with High Cognitive Function (HCF) or Low Cognitive Function (LCF) based on their scores on the ADAS-Cog. Method: Thirty-eight participants aged 65 or older and living independently in the community followed a twice-daily vitamin C regimen for 5 weeks. Adherence was measured using an electronic 7-day pillbox. Results: The LCF group had significantly poorer total adherence than the HCF group (LCF: 63.9 ± 11.2%, HCF: 86.8 ± 4.3%, t 36 = 2.57, p =.007), and there was a 4.1 relative risk of non-adherence in the LCF group as compared to the HCF group. Discussion: This study has important implications for the conduct of clinical drug trials, as it provides strong evidence that even very mild cognitive impairment in healthy elderly has a detrimental impact on medication adherence.

Original languageEnglish (US)
Pages (from-to)567-580
Number of pages14
JournalJournal of Aging and Health
Volume21
Issue number4
DOIs
StatePublished - Jun 2009

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Medication Adherence
Cognition
medication
Group
Aptitude
cross-sectional study
Ascorbic Acid
Cross-Sectional Studies
Clinical Trials
electronics
drug
ability
Pharmaceutical Preparations

Keywords

  • Adherence
  • Cognitive impairment
  • Medication

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Community and Home Care

Cite this

Medication adherence in healthy elders : Small cognitive changes make a big difference. / Hayes, Tamara L.; Larimer, Nicole; Adami, Andre; Kaye, Jeffrey.

In: Journal of Aging and Health, Vol. 21, No. 4, 06.2009, p. 567-580.

Research output: Contribution to journalArticle

Hayes, Tamara L. ; Larimer, Nicole ; Adami, Andre ; Kaye, Jeffrey. / Medication adherence in healthy elders : Small cognitive changes make a big difference. In: Journal of Aging and Health. 2009 ; Vol. 21, No. 4. pp. 567-580.
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