Medial axis segmentation of cranial nerves using shape statistics-aware discrete deformable models

Sharmin Sultana, Praful Agrawal, Shireen Elhabian, Ross Whitaker, Jason E. Blatt, Benjamin Gilles, Justin Cetas, Tanweer Rashid, Michel A. Audette

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Purpose: We propose a segmentation methodology for brainstem cranial nerves using statistical shape model (SSM)-based deformable 3D contours from T2 MR images. Methods: We create shape models for ten pairs of cranial nerves. High-resolution T2 MR images are segmented for nerve centerline using a 1-Simplex discrete deformable 3D contour model. These segmented centerlines comprise training datasets for the shape model. Point correspondence for the training dataset is performed using an entropy-based energy minimization framework applied to particles located on the centerline curve. The shape information is incorporated into the 1-Simplex model by introducing a shape-based internal force, making the deformation stable against low resolution and image artifacts. Results: The proposed method is validated through extensive experiments using both synthetic and patient MRI data. The robustness and stability of the proposed method are experimented using synthetic datasets. SSMs are constructed independently for ten pairs (CNIII–CNXII) of brainstem cranial nerves using ten non-pathological image datasets of the brainstem. The constructed ten SSMs are assessed in terms of compactness, specificity and generality. In order to quantify the error distances between segmented results and ground truths, two metrics are used: mean absolute shape distance (MASD) and Hausdorff distance (HD). MASD error using the proposed shape model is 0.19 ± 0.13 (mean ± std. deviation) mm and HD is 0.21 mm which are sub-voxel accuracy given the input image resolution. Conclusion: This paper described a probabilistic digital atlas of the ten brainstem-attached cranial nerve pairs by incorporating a statistical shape model with the 1-Simplex deformable contour. The integration of shape information as a priori knowledge results in robust and accurate centerline segmentations from even low-resolution MRI data, which is essential in neurosurgical planning and simulations for accurate and robust 3D patient-specific models of critical tissues including cranial nerves.

Original languageEnglish (US)
Pages (from-to)1955-1967
Number of pages13
JournalInternational Journal of Computer Assisted Radiology and Surgery
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2019

Keywords

  • 3D contour models
  • Brainstem
  • Centerline
  • Cranial nerves
  • Deformable models
  • MRI
  • Segmentation
  • Statistical shape models
  • Surgical guidance

ASJC Scopus subject areas

  • Surgery
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Science Applications
  • Computer Graphics and Computer-Aided Design

Fingerprint Dive into the research topics of 'Medial axis segmentation of cranial nerves using shape statistics-aware discrete deformable models'. Together they form a unique fingerprint.

  • Cite this