Mechanistic link between DNA methyltransferases and DNA repair enzymes by base flipping

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Rotation of a DNA nucleotide out of the double helix and into a protein binding pocket ('base flipping') was first observed in the structure of a DNA methyltransferase. There is now evidence that a variety of proteins, particularly DNA repair enzymes, use base flipping in their interactions with DNA. Though the mechanisms for base movement into extrahelical positions are still unclear, the focus of this review is how base recognition is modulated by the stringency of binding to the extrahelical base(s) or sugar moiety.

Original languageEnglish (US)
Pages (from-to)139-151
Number of pages13
JournalBiopolymers - Nucleic Acid Sciences Section
Volume44
Issue number2
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

DNA Repair Enzymes
Methyltransferases
DNA
Nucleotides
Protein Binding
Sugars
Proteins

Keywords

  • Base flipping
  • DNA methyltransferases
  • DNA repair enzymes
  • Extrahelical nucleotide

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics

Cite this

Mechanistic link between DNA methyltransferases and DNA repair enzymes by base flipping. / Lloyd, Robert (Stephen); Cheng, X.

In: Biopolymers - Nucleic Acid Sciences Section, Vol. 44, No. 2, 1997, p. 139-151.

Research output: Contribution to journalArticle

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