Mechanisms of ischemic brain damage

Kristian P. Doyle, Roger P. Simon, Mary Stenzel-Poore

Research output: Contribution to journalArticle

504 Citations (Scopus)

Abstract

In the United States stroke is the third leading cause of death and the leading cause of disability. Brain injury following stroke results from the complex interplay of multiple pathways including excitotoxicity, acidotoxicity, ionic imbalance, peri-infarct depolarization, oxidative and nitrative stress, inflammation and apoptosis. There are very few treatments for stroke and the development of new treatments requires a comprehensive understanding of the diverse mechanisms of ischemic brain damage that are responsible for neuronal death. Here, we discuss the underlying pathophysiology of this devastating disease and reveal the intertwined pathways that are the target of therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)310-318
Number of pages9
JournalNeuropharmacology
Volume55
Issue number3
DOIs
StatePublished - Sep 2008

Fingerprint

Stroke
Brain
Brain Injuries
Cause of Death
Oxidative Stress
Apoptosis
Inflammation
Therapeutics

Keywords

  • acidotoxicity
  • apoptosis
  • combinatorial therapy
  • excitotoxicity
  • Inflammation
  • ischemia
  • Stroke

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Mechanisms of ischemic brain damage. / Doyle, Kristian P.; Simon, Roger P.; Stenzel-Poore, Mary.

In: Neuropharmacology, Vol. 55, No. 3, 09.2008, p. 310-318.

Research output: Contribution to journalArticle

Doyle, Kristian P. ; Simon, Roger P. ; Stenzel-Poore, Mary. / Mechanisms of ischemic brain damage. In: Neuropharmacology. 2008 ; Vol. 55, No. 3. pp. 310-318.
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