Mechanisms of Ion Transport Regulation by Microfilaments

Zhihong Hu, Daniel R. Clayburgh, Jerrold R. Turner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A major function of transporting epithelia is vectorial ion movement. This is accomplished by ion channels, pumps, antiporters, and symporters. The activity of these transport proteins is regulated by diverse signaling transduction and membrane trafficking events, many of which involve the actin cytoskeleton. This chapter will focus on the role of actin microfilaments and associated proteins in regulation of ion transport. The apical Na+H+ antiporter NHE3 will be examined in detail in this context due to its general biological importance as well as recent advances that have helped to elucidate the mechanisms of regulation of this protein. Appreciation of the mechanisms of NHE3 regulation should serve as a framework with which to understand cytoskeletal regulation of other transport proteins as well.

Original languageEnglish (US)
Title of host publicationAspects of the Cytoskeleton
EditorsEdward Bittar, Seema Khurana
Pages285-305
Number of pages21
DOIs
StatePublished - Dec 4 2006

Publication series

NameAdvances in Molecular and Cell Biology
Volume37
ISSN (Print)1569-2558

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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  • Cite this

    Hu, Z., Clayburgh, D. R., & Turner, J. R. (2006). Mechanisms of Ion Transport Regulation by Microfilaments. In E. Bittar, & S. Khurana (Eds.), Aspects of the Cytoskeleton (pp. 285-305). (Advances in Molecular and Cell Biology; Vol. 37). https://doi.org/10.1016/S1569-2558(06)37013-0