Mechanisms of Ion Transport Regulation by Microfilaments

Zhihong Hu, Daniel Clayburgh, Jerrold R. Turner

Research output: Contribution to journalArticle

Abstract

A major function of transporting epithelia is vectorial ion movement. This is accomplished by ion channels, pumps, antiporters, and symporters. The activity of these transport proteins is regulated by diverse signaling transduction and membrane trafficking events, many of which involve the actin cytoskeleton. This chapter will focus on the role of actin microfilaments and associated proteins in regulation of ion transport. The apical Na+H+ antiporter NHE3 will be examined in detail in this context due to its general biological importance as well as recent advances that have helped to elucidate the mechanisms of regulation of this protein. Appreciation of the mechanisms of NHE3 regulation should serve as a framework with which to understand cytoskeletal regulation of other transport proteins as well.

Original languageEnglish (US)
Pages (from-to)285-305
Number of pages21
JournalAdvances in Molecular and Cell Biology
Volume37
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Ion Transport
Actin Cytoskeleton
Carrier Proteins
Ion Pumps
Antiporters
Symporters
Microfilament Proteins
Sodium-Hydrogen Antiporter
Ion Channels
Epithelium
Ions
Membranes
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Mechanisms of Ion Transport Regulation by Microfilaments. / Hu, Zhihong; Clayburgh, Daniel; Turner, Jerrold R.

In: Advances in Molecular and Cell Biology, Vol. 37, 2006, p. 285-305.

Research output: Contribution to journalArticle

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