Mechanisms of interference with the MHC class I-restricted pathway of antigen presentation by herpesviruses

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentation, suggesting that impairment of the cytotoxic T lymphocyte response is necessary for the maintenance of this lifestyle. The diverse molecular mechanisms that have so far been discovered employed by Epstein-Barr virus, herpes simplex viruses, and human and murine cytomegaloviruses are described in this review.

Original languageEnglish (US)
Pages (from-to)523-526
Number of pages4
JournalImmunology and Cell Biology
Volume74
Issue number6
DOIs
StatePublished - Jan 1 1996

Keywords

  • Epstein-Barr virus
  • MHC class I
  • antigen presentation
  • cytomegalovirus
  • cytotoxic T lymphocyte
  • herpes simplexvirus
  • herpesvirus
  • latency
  • natural killer cell
  • transporter associated with antigen processing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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