Mechanisms of interference with the MHC class I-restricted pathway of antigen presentation by herpesviruses

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentation, suggesting that impairment of the cytotoxic T lymphocyte response is necessary for the maintenance of this lifestyle. The diverse molecular mechanisms that have so far been discovered employed by Epstein-Barr virus, herpes simplex viruses, and human and murine cytomegaloviruses are described in this review.

Original languageEnglish (US)
Pages (from-to)523-526
Number of pages4
JournalImmunology and Cell Biology
Volume74
Issue number6
StatePublished - 1996

Fingerprint

Herpesviridae
Antigen Presentation
Viruses
Life Style
Muromegalovirus
Antigens
DNA Viruses
Cytotoxic T-Lymphocytes
Simplexvirus
Human Herpesvirus 4
T-cells
Maintenance
DNA

Keywords

  • antigen presentation
  • cytomegalovirus
  • cytotoxic T lymphocyte
  • Epstein-Barr virus
  • herpes simplexvirus
  • herpesvirus
  • latency
  • MHC class I
  • natural killer cell
  • transporter associated with antigen processing

ASJC Scopus subject areas

  • Immunology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Mechanisms of interference with the MHC class I-restricted pathway of antigen presentation by herpesviruses. / Hill, Ann.

In: Immunology and Cell Biology, Vol. 74, No. 6, 1996, p. 523-526.

Research output: Contribution to journalArticle

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