Mechanisms of Inflammation in Neutrophil-Mediated Skin Diseases

Angelo V. Marzano, Alex Ortega Loayza, Michael Heath, Daniel Morse, Giovanni Genovese, Massimo Cugno

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Neutrophil-mediated skin diseases, originally named neutrophilic dermatoses (NDs), are a group of conditions due to an altered neutrophil recruitment and activation, characterized by polymorphic cutaneous manifestations with possible internal organ involvement. Although a number of diseases are included in this setting, the two prototypic forms are pyoderma gangrenosum (PG) and Sweet's syndrome (SS) which usually present with skin ulcers and plaque-type lesions, respectively. They have central features significantly overlapping with autoinflammatory conditions which manifest as repeated episodes of tissue inflammation. However, in contrast to appropriate inflammatory responses to insults or to autoimmune disease, there is an absence of identifiable pathogens, autoantibodies, or autoreactive lymphocytes. The recognition of monogenic autoinflammatory diseases which can present with NDs has led to study several genes involved in autoinflammation in NDs. Based on discovering of a number of mutations involving different autoinflammatory genes, neutrophil-mediated skin diseases are nowadays regarded as a spectrum of polygenic autoinflammatory conditions. Although disease mechanisms have not yet been completely elucidated, NDs are recognized as diseases involving dysfunctional cellular signaling mediated by pathways mainly related to inflammasome and IL-1 with the contributory role of IL-17 and other effector molecules. The precise elucidation of the above-mentioned pathologic mechanisms may pave the way to tailored treatments for patients with different neutrophil-mediated skin diseases.

Original languageEnglish (US)
Number of pages1
JournalFrontiers in immunology
Volume10
DOIs
StatePublished - Jan 1 2019

Fingerprint

Skin Diseases
Neutrophils
Inflammation
Sweet Syndrome
Inflammasomes
Skin Ulcer
Pyoderma Gangrenosum
Skin Manifestations
Neutrophil Activation
Interleukin-17
Neutrophil Infiltration
Interleukin-1
Autoantibodies
Genes
Autoimmune Diseases
Lymphocytes
Mutation

Keywords

  • autoinflammation
  • cytokines
  • inflammasome
  • neutrophil-mediated skin diseases
  • pyoderma gangrenosum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Mechanisms of Inflammation in Neutrophil-Mediated Skin Diseases. / Marzano, Angelo V.; Ortega Loayza, Alex; Heath, Michael; Morse, Daniel; Genovese, Giovanni; Cugno, Massimo.

In: Frontiers in immunology, Vol. 10, 01.01.2019.

Research output: Contribution to journalReview article

Marzano, Angelo V. ; Ortega Loayza, Alex ; Heath, Michael ; Morse, Daniel ; Genovese, Giovanni ; Cugno, Massimo. / Mechanisms of Inflammation in Neutrophil-Mediated Skin Diseases. In: Frontiers in immunology. 2019 ; Vol. 10.
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