Mechanisms of cytomegalovirus disease

C. Soderberg-Naucler, K. N. Fish, Jay Nelson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

With the growing numbers of patients immunocompromised by AIDS or organ/bone marrow transplants, cytomegalovirus (CMV) infection has become a major cause for concern. Cytomegalovirus remains a leading cause of morbidity and mortality in these patient groups, despite the advent of new drugs and prophylactic strategies. During acute disease the virus can infect a variety of cell types, including cells of epithelial origin as well as endothelial and infiltrating inflammatory cells. Although the sites of viral persistence have not been identified, cells of the monocytic and endothelial linages are likely candidates for maintaining persistence in the human host. Immunosuppression commonly results in the reactivation of latent virus, and is followed by a variety of different disease processes. The mechanism through which CMV produces disease is most likely through direct tissue damage, but indirect immunological mechanisms may also play a role.

Original languageEnglish (US)
Pages (from-to)4-9
Number of pages6
JournalHerpes
Volume4
Issue number1
StatePublished - 1997

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Cytomegalovirus
Endothelial Cells
Viruses
Cytomegalovirus Infections
Immunocompromised Host
Acute Disease
Immunosuppression
Acquired Immunodeficiency Syndrome
Bone Marrow
Epithelial Cells
Morbidity
Transplants
Mortality
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Virology
  • Dermatology

Cite this

Soderberg-Naucler, C., Fish, K. N., & Nelson, J. (1997). Mechanisms of cytomegalovirus disease. Herpes, 4(1), 4-9.

Mechanisms of cytomegalovirus disease. / Soderberg-Naucler, C.; Fish, K. N.; Nelson, Jay.

In: Herpes, Vol. 4, No. 1, 1997, p. 4-9.

Research output: Contribution to journalArticle

Soderberg-Naucler, C, Fish, KN & Nelson, J 1997, 'Mechanisms of cytomegalovirus disease', Herpes, vol. 4, no. 1, pp. 4-9.
Soderberg-Naucler C, Fish KN, Nelson J. Mechanisms of cytomegalovirus disease. Herpes. 1997;4(1):4-9.
Soderberg-Naucler, C. ; Fish, K. N. ; Nelson, Jay. / Mechanisms of cytomegalovirus disease. In: Herpes. 1997 ; Vol. 4, No. 1. pp. 4-9.
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