Mechanisms of corticosteroid action on lymphocyte subpopulations. VI. Lack of correlation between glucocorticosteroid receptors and the differential effects of glucocorticosteroids on T-cell subpopulations

Anthony S. Fauci, Tohru Murakami, David D. Brandon, D. Lynn Loriaux, Mortimer B. Lipsett

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Glucocorticosteroid receptors were measured in subpopulations of human peripheral blood T cells identified by the presence of an Fc receptor for IgG (TG) or an Fc receptor for IgM (TM). TM cells are selectively depleted from the circulation by in vivo administration of glucocorticosteroids as opposed to TG cells which are relatively resistant to the lymphodepletive effects of these hormones. However, this selective lymphodepletive effect of glucocorticosteroids on TM cells could not be explained on the basis of detectable differences in intracytoplasmic glucocorticosteroid receptors in these T-cell subpopulations since TG and TM cells had quantitatively similar glucocorticosteroid receptors as well as remarkably similar dexamethasone binding affinities and dissociation constants. Hence, the strikingly different effects of glucocorticosteroids on the circulatory kinetics of TG and TM cells must be explained by mechanisms other than those at the level of the glucocorticosteroid receptor.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalCellular Immunology
Volume49
Issue number1
DOIs
StatePublished - Jan 1980

ASJC Scopus subject areas

  • Immunology

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