Mechanisms of chromatin assembly and transcription

Shilpa Kadam, Beverly M. Emerson

Research output: Contribution to journalReview article

56 Scopus citations

Abstract

Fundamental mechanisms that regulate chromatin assembly and transcription have been elucidated recently using genetics and highly defined biochemical systems. Once DNA is packaged into chromatin, its function is controlled by the ordered recruitment of diverse enzymatic complexes that structurally remodel or chemically modify nucleosomes. Recent studies provide insight into the functional selectivity of chromatin-remodeling and -modifying complexes and how they act in specific combinations to regulate individual genes and cellular pathways.

Original languageEnglish (US)
Pages (from-to)262-268
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume14
Issue number3
DOIs
StatePublished - Jun 1 2002

ASJC Scopus subject areas

  • Cell Biology

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